Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: A systematic review of SARS-CoV-2 vaccine candidates

Fig. 4

NAbs isolation strategies. a mAbs can be isolated from convalescent people previously infected with virus. After sorting antigen-specific B cells, deep sequencing can help pair the heavy- and light-chain genes. Selected pairs via functional screening can be used to produce mAbs. b Humanized mAbs can be isolated from immunized transgenic animal models, like mice. c Nanobodies can be constructed based on sequences of the camelid immunized with viral proteins and produced by phage carrying the VHH encoding sequences

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