Fig. 8 | Signal Transduction and Targeted Therapy

Fig. 8

From: Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages

Fig. 8

Proposed hypothesis for the prevention of colorectal peritoneal metastasis by a HFD. Disseminated colorectal cancer cells preferentially target the visceral fat in early metastasis. HFD consumption stimulates TLR4-dependent M1 macrophage activation and phagocytosis in adipose tissue macrophages (ATMs), which further enhance the recruitment (by Cxcl10) and activation (by M1 cytokines) of CD4+ and CD8+ T cells in the visceral fat and ultimately prevents the metastatic seeding of colorectal cancer

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