Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance

Fig. 1

Suppressed HNF3γ expression in patient HCC tissues. a mRNA expression of HNF3γ in 63 pairs of HCC (T) and peri-tumoral normal (N) tissues was determined by real-time PCR. The majority of patients (77.8%) exhibited reduced HNF3γ expression in HCC tissues. b Western blotting assay of HNF3γ expression in 18 peri-tumoral normal (N) and paired HCC (T) tissues. c Representative views of HNF3γ expression in 156 paired HCC and peri-tumoral normal tissues from Cohort 1 after IHC staining. The majority of patients (73.2%) exhibited decreased HNF3γ expression in HCC tissues. Scale bar, 100 μm. d HNF3γ expression was compared between 17 paired normal peri-tumoral, primary HCC, and PVTT tissues by real-time PCR (*p < 0.05). e, f HNF3γ levels were compared between 21 pairs of peri-tumoral normal, primary HCC, and recurrent tumor tissues by IHC staining. Representative images are shown. Scale bar, 100 μm

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