Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells

Fig. 3

GLPT downregulates the expression of the antiapoptotic proteins Bcl-xL and survivin and upregulates the expression of DR4 and DR5, leading to activation of caspase 3/8 and cleavage of PARP. a, b A549 and A427 cells were treated with GLPT for 24 h at the indicated concentrations, and western blotting was then performed with the indicated antibodies. GAPDH or β-tubulin served as a loading control

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