Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Proteomics promises a new era of precision cancer medicine

Fig. 1

Overview of multi-omics analyses of HBV-related early-stage HCC. The proteomic and phospho-proteomic landscapes of 101 paired tumor and nontumor tissues of early-stage HCC were examined. Based on these data, early-stage HCCs were stratified into three major proteomic subtypes: S-I, S-II, and S-III. All three subtypes of HCC were characterized, and the drug-targetable candidate protein SOAT1 was identified in S-III. They also integrated the proteome information with genome and transcriptome data, and performed a comparative analysis, mapping the new-dimensional findings onto the literature-derived classifications. All the multi-omics data are stored in a data portal at http://liver.cnhpp.ncpsb.org/

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