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Histopathological concordance between prostate biopsies and radical prostatectomy specimens—implications of transrectal and transperineal biopsy approaches



This study aimed to evaluate the histopathological concordance rates between prostate biopsies and radical prostatectomy specimens according to the applied biopsy approach (transrectal or transperineal).


We studied patients who had been newly diagnosed with clinically significant prostate cancer and who underwent a radical prostatectomy between 2018 and 2022. Patients were included if they underwent a prebiopsy magnetic resonance imaging and if they had not been previously treated for prostate cancer. Histopathological grading on prostate biopsies was compared with that on radical prostatectomy specimens. Univariable and multivariable logistic regression analyses were performed to assess the effect of the applied biopsy approach on histopathological concordance. Additional analyses were performed to assess the effect of the applied biopsy approach on American Urological Association risk group migration, defined as any change in risk group after radical prostatectomy.


In total, 1058 men were studied, of whom 49.3% (522/1058) and 50.7% (536/1058) underwent transrectal and transperineal prostate biopsies, respectively. Histopathological disconcordance was observed in 37.8% (400/1058) of men while American Urological Association risk group migration was observed in 30.2% (320/1058) of men. A transperineal biopsy approach was found to be independently associated with higher histopathological concordance rates (OR 1.33 [95% CI 1.01–1.75], p = 0.04) and less American Urological Association risk group migration (OR 0.70 [95% CI 0.52–0.93], p = 0.01).


The use of a transperineal biopsy approach improved histopathological concordance rates compared to the use of a transrectal biopsy approach. A transperineal biopsy approach may provide more accurate risk stratification for clinical decision-making. Despite recent improvements, histopathologic concordance remains suboptimal and should be considered before initiating management.

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Data availability

The research data for this study is available from the corresponding authors on reasonable requests.


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Authors and Affiliations



Study concept and design: MH, LR, PVL, HVP; Statistical Analysis: MH, LR, VVN; Interpretation: MH, LR, PVL, HVP; Initial drafting of manuscript: MH, LR; Critical review: AJ, HV, KB, BB, RDB, AC, ML, MS, TR, SR, MS, SW, AV, PVL, HVP.

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Correspondence to M. J. Hagens.

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Hagens, M.J., Ribbert, L.L.A., Jager, A. et al. Histopathological concordance between prostate biopsies and radical prostatectomy specimens—implications of transrectal and transperineal biopsy approaches. Prostate Cancer Prostatic Dis (2023).

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