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Fact, overdiagnosis cannot be evaluated by comparing histological grading of prostate biopsy to prostatectomy specimen

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  1. Martini A, Touzani A, Mazzone E, Roumiguié M, Marra G, Valerio M, et al. Overdiagnosis and stage migration of ISUP 2 disease due to mpMRI-targeted biopsy: facts or fictions. Prostate Cancer Prostatic Dis. 2022.

  2. Hamdy FC, Donovan JL, Lane JA, Mason M, Metcalfe C, Holding P, et al. 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N. Engl J Med. 2016;375:1415–24.

    Article  Google Scholar 

  3. Boesen L, Nørgaard N, Løgager V, Balslev I, Bisbjerg R, Thestrup KC, et al. Prebiopsy biparametric magnetic resonance imaging combined with prostate-specific antigen density in detecting and ruling out Gleason 7–10 prostate cancer in biopsy-naïve men. Eur Urol Oncol. 2019; 2.

  4. Kawa SM, Stroomberg HV, Larsen SB, Helgstrand JT, Toft BG, Vickers AJ, et al. A nationwide analysis of risk of prostate cancer diagnosis and mortality following an initial negative TRUS-biopsy with long-term follow-up. J Urol. 2022;208:100–8.

    Article  Google Scholar 

  5. Hilscher M, Røder A, Helgstrand JT, Klemann N, Brasso K, Vickers AJ, et al. Risk of prostate cancer and death after benign transurethral resection of the prostate—A 20‐year population‐based analysis. Cancer. 2022;128:3674–3680.

    Article  Google Scholar 

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Conceptualization: HVS, KB, AR; Writing – Original Draft: HVS; Writing – Review & Editing: HVS, KB, AR.

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Correspondence to Hein Vincent Stroomberg.

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Stroomberg, H.V., Brasso, K. & Røder, A. Fact, overdiagnosis cannot be evaluated by comparing histological grading of prostate biopsy to prostatectomy specimen. Prostate Cancer Prostatic Dis (2022).

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