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Quality of life in men with metastatic castration-resistant prostate cancer treated with enzalutamide or abiraterone: a systematic review and meta-analysis

Abstract

Background

Enzalutamide and abiraterone acetate plus prednisone (AAP) have similar efficacy in metastatic castration-resistant prostate cancer (mCRPC), but different mechanisms of action. The aim was to compare patient-reported health-related quality of life (HRQoL) in men treated with enzalutamide vs AAP for mCRPC.

Methods

We systematically reviewed the literature in June 2020 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Patient-reported outcomes (PROs) until the last follow-up were summarised in a narrative synthesis. Short-term changes (12 weeks) in HRQoL, measured by the Functional Assessment of Cancer Therapy-Prostate total score (FACT-P), were compared between treatment groups and were analysed for enzalutamide and AAP in separate meta-analyses. Higher FACT-P scores indicate better HRQoL.

Results

Eight studies were included in the systematic review, four of which were randomised clinical trials (RCTs) eligible for the meta-analyses. The meta-analyses showed mean within-subject FACT-P changes from baseline to week 12 of −1.3 points (95% confidence interval [CI] −2.7; 0.1) for enzalutamide and 4.7 points (95% CI −0.1; 9.6) for AAP.

One RCT and three non-randomised studies directly compared enzalutamide with AAP. The RCT showed better short-term HRQoL for AAP (6.8 FACT-P-points, 95% CI 1.7; 11.8) and better long-term HRQoL for AAP in men ≥75 years (7.35 FACT-P-points, 95% CI 2.59; 12.11). The non-randomised studies showed no difference in long-term HRQoL but had all a serious risk of bias.

Limitations of the included studies include that the PRO in the included trials were inconsistently reported and that only one study defined the HRQoL measures in their published protocol.

Conclusions

AAP seems to be associated with better short-term HRQoL than enzalutamide. This difference was not apparent at longer follow-up, but the long-term studies had serious risks of bias.

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Fig. 1: PRISMA flow diagram.
Fig. 2: Risk of bias summary.
Fig. 3: Changed short-term health-related quality of life.

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Acknowledgements

Support: No external grants or funds were used to support this research. Following statement refers to the COU-AA-302 data, used in the meta-analysis, obtained via the Yale University Open Data Access (YODA) project: “This study, carried out under YODA Project # 2019-3990, used data obtained from the Yale University Open Data Access Project, which has an agreement with JANSSEN RESEARCH & DEVELOPMENT, L.L.C. The interpretation and reporting of research using this data are solely the responsibility of the authors and does not necessarily represent the official views of the Yale University Open Data Access Project or JANSSEN RESEARCH & DEVELOPMENT, L.L.C.”.

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All authors contributed to the design of study and interpretation of the results as well as read, reviewed and approved the final manuscript. KKT and ABN screened full text publications. KKT and OB assessed risk of bias and evidence graded the included studies. KKT and TWK made the statistical analyses. KKT and PBO drafted the manuscript. All authors critically reviewed the manuscript.

Corresponding author

Correspondence to Klara Kvorning Ternov.

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Conflict of interest

MF is an advisor and speaker for Ferring and Astellas. PBO has been a speaker for Astellas, Ipsen and Ferring. HL is an advisor for Roche, Janssen, Astellas, Bayer and Sanofi-Aventis. OB has been speaker and moderator at non-product specific meetings arranged by AstraZeneca, Janssen, Amgen, Astellas, Ipsen and Bayer. KKT, ABN, CK, GP, and JS and TWK declare no potential conflicts of interest.

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Ternov, K.K., Nolsøe, A.B., Bratt, O. et al. Quality of life in men with metastatic castration-resistant prostate cancer treated with enzalutamide or abiraterone: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis 24, 948–961 (2021). https://doi.org/10.1038/s41391-021-00359-8

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