Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Risk of childhood cancer in infants treated with phototherapy for neonatal jaundice

The Original Article was published on 13 April 2024

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Cremer, R. J., Perryman, P. W. & Richards, D. H. Influence of light on the hyperbilirubinemia of infants. Lancet 1, 1094–1097 (1958).

    Article  CAS  PubMed  Google Scholar 

  2. Lucey, J., Ferriero, M. & Hewitt, J. Prevention of hyperbilirubinemia of prematurity by phototherapy. Pediatrics 41, 1047–1054 (1968).

    Article  CAS  PubMed  Google Scholar 

  3. Bhutani, V. K. Editorial: building evidence to manage newborn jaundice worldwide. Indian J. Pediatr. 79, 253–255 (2012).

    Article  PubMed  Google Scholar 

  4. Speck, W. T. & Rosenkranz, H. S. The bilirubin-induced photodegradation of deoxyribonucleic acid. Pediatr. Res. 9, 703–705 (1975).

    Article  CAS  PubMed  Google Scholar 

  5. Tatli, M. M., Minnet, C., Kocyigit, A. & Karadag, A. Phototherapy increases DNA damage in lymphocytes of hyperbilirubinemic neonates. Mutat. Res. 654, 93–95 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Cnattingius, S. et al. Prenatal and neonatal risk factors for childhood myeloid leukemia. Cancer Epidemiol. Biomark. Prev. 4, 441–445 (1995).

    CAS  Google Scholar 

  7. Cnattingius, S. et al. Prenatal and neonatal risk factors for childhood lymphatic leukemia. J. Natl Cancer Inst. 87, 908–914 (1995).

    Article  CAS  PubMed  Google Scholar 

  8. Hemati, Z., Keikha, M., Khoshhali, M. & Kelishadi, R. Phototherapy and risk of childhood cancer: A systematic review and meta-analysis. J. Neonat. Nurs. 28, 219–228 (2022).

    Article  Google Scholar 

  9. Kuitunen I., Nikkila A., Kiviranta P., Jaaskelainen J. & Auvinen A. Risk of childhood neoplasms related to neonatal phototherapy- a systematic review and meta-analysis. Pediatr. Res. (2024). Online ahead of print.

  10. Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. & Southall, M. D. Irradiation of skin with visible light induces reactive oxygen species and matrix-degrading enzymes. J. Invest Dermatol 132, 1901–1907 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. Gathwala, G. & Sharma, S. Phototherapy induces oxidative stress in premature neonates. Indian J. Gastroenterol. 21, 153–154 (2002).

    PubMed  Google Scholar 

  12. Cole C. & Forbes P. D. Examining the role of visible light in photocarcinogenesis – Lessons from the past. J. Photochem. Photobiol 17, 100201 (2023).

  13. Jasprova, J. et al. A novel accurate LC-MS/MS method for quantitative determination of Z-lumirubin. Sci. Rep. 10, 4411 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Jasprova, J. et al. Neuro-inflammatory effects of photodegradative products of bilirubin. Sci. Rep. 8, 7444 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Capkova, N. et al. The effects of bilirubin and lumirubin on the differentiation of human pluripotent cell-derived neural stem cells. Antioxid. (Basel) 10, 1532 (2021).

    Article  CAS  Google Scholar 

  16. Vitek, L. Bilirubin as a signaling molecule. Med Res Rev. 40, 1335–1351 (2020).

    Article  CAS  PubMed  Google Scholar 

  17. Vitek, L. & Tiribelli, C. Bilirubin: The yellow hormone? J. Hepatol. 75, 1485–1490 (2021).

    Article  CAS  PubMed  Google Scholar 

  18. Mujawar T., Sevelda P., Madea D., Klan P. & Svenda J. A platform for the synthesis of oxidation products of bilirubin. J. Am. Chem. Soc. https://doi.org/10.1021/jacs.3c11778 (2024).

Download references

Funding

Funding

Supported by grants MH CZ-DRO-VFN64165 from the Czech Ministry of Health; Cooperation Program, research area DIAG given by Charles University, and the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES LX22NPO5104) funded by the European Union-Next Generation EU.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Libor Vítek.

Ethics declarations

Competing interests

The author declares no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vítek, L. Risk of childhood cancer in infants treated with phototherapy for neonatal jaundice. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03315-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41390-024-03315-z

Search

Quick links