Abstract
While perinatal medicine advancements have bolstered survival outcomes for premature infants, bronchopulmonary dysplasia (BPD) continues to threaten their long-term health. Gene–environment interactions, mediated by epigenetic modifications such as DNA methylation, histone modification, and non-coding RNA regulation, take center stage in BPD pathogenesis. Recent discoveries link methylation variations across biological pathways with BPD. Also, the potential reversibility of histone modifications fuels new treatment avenues. The review also highlights the promise of utilizing mesenchymal stem cells and their exosomes as BPD therapies, given their ability to modulate non-coding RNA, opening novel research and intervention possibilities.
Impact
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The complexity and universality of epigenetic modifications in the occurrence and development of bronchopulmonary dysplasia were thoroughly discussed.
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Both molecular and cellular mechanisms contribute to the diverse nature of epigenetic changes, suggesting the need for deeper biochemical techniques to explore these molecular alterations.
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The utilization of innovative cell-specific drug delivery methods like exosomes and extracellular vesicles holds promise in achieving precise epigenetic regulation.
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Data availability
This review article does not contain any primary data collection, and therefore, no new data were generated or analyzed as part of this study. The article is based solely on a comprehensive literature review of existing publications, which are cited within the text.
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Acknowledgements
We wish to thank Ana Hou for guidance and support during the completion of this review. Figures were created using biorender.com.
Funding
The study was supported by grants from the Social Development Major Projects of Liaoning Province (2020JH1/1030001), Key Research and Development Program Joint Program of Liaoning Province (2020JH2/10300132), Public Welfare Fund of China Foundation for International Medical Exchange (z-2019-41-2101-04), and the 345lent project of the China Medical University affiliated Shengjing Hospital.
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L.W., A.H., J.X., and B.Z. collaborated on the extensive literature search. L.W. took on the pivotal role of drafting the initial manuscript and spearheading the systematic literature review. A.H. contributed valuable insights by critically appraising the manuscript with a focus on intellectual content. J.X. and B.Z. provided essential support in the meticulous preparation of the manuscript.
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Wang, L., Xiao, J., Zhang, B. et al. Epigenetic modifications in the development of bronchopulmonary dysplasia: a review. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03167-7
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DOI: https://doi.org/10.1038/s41390-024-03167-7