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The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Wyckoff, M. H., Weiner, G. M. & Neonatal Life Support Collaborators. 2020 International Consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Pediatrics 147, e2020038505C (2021).
Halling, C., Sparks, J. E., Christie, L. & Wyckoff, M. H. Efficacy of intravenous and endotracheal epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. J. Pediatr. 185, 232–236 (2017).
Andersen, H. B. et al. Epinephrine vs placebo in neonatal resuscitation: ROSC and brain MRS/MRI in term piglets. Pediatr. Res. (2022).
Barber, C. A. & Wyckoff, M. H. Use and efficacy of endotracheal versus intravenous epinephrine during neonatal cardiopulmonary resuscitation in the delivery room. Pediatrics 118, 1028–1034 (2006).
Vali, P. et al. Evaluation of timing and route of epinephrine in a neonatal model of asphyxial arrest. J. Am. Heart Assoc. 6, e004402 (2017).
Sankaran, D. et al. Effect of a larger flush volume on bioavailability and efficacy of umbilical venous epinephrine during neonatal resuscitation in ovine asphyxial arrest. Children (Basel) 8, 464 (2021).
Sankaran, D. et al. Randomised trial of epinephrine dose and flush volume in term newborn lambs. Arch. Dis. Child Fetal Neonatal Ed. 106, 578–583 (2021).
Bruckner, M. et al. Assessment of optimal chest compression depth during neonatal cardiopulmonary resuscitation: a randomised controlled animal trial. Arch. Dis. Child Fetal Neonatal Ed. 107, 262–268 (2022).
Foglia, E. E. et al. Duration of resuscitation at birth, mortality, and neurodevelopment: a systematic review. Pediatrics 146, e20201449 (2020).
Foglia, E. E. et al. Survival after delivery room cardiopulmonary resuscitation: a national registry study. Resuscitation 152, 177–183 (2020).
Roberts, C. T. et al. Comparison of intraosseous and intravenous epinephrine administration during resuscitation of asphyxiated newborn lambs. Arch. Dis. Child Fetal Neonatal Ed. 107, 311–316 (2022).
Vali, P., Weiner, G. M., Sankaran, D. & Lakshminrusimha, S. What is the optimal initial dose of epinephrine during neonatal resuscitation in the delivery room? J. Perinatol. 41, 1769–1773 (2021).
Laptook, A. R. et al. Outcome of term infants using Apgar scores at 10 min following hypoxic-ischemic encephalopathy. Pediatrics 124, 1619–1626 (2009).
Hagihara, A. et al. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA 307, 1161–1168 (2012).
Mike, J. K. et al. An ovine model of perinatal hypoxic-ischemic encephalopathy with resultant motor impairment aimed at low resource settings. Dev. Neurosci. (2022).
This work was supported in part by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 5 R01 HD072929 09 (S.L.), and research grant from the American Academy of Pediatrics-Neonatal Resuscitation Program (D.S.), and Children’s Miracle Network at UC Davis Pediatrics (D.S.).
The named authors have no conflict of interest, financial or otherwise. S.L. is a member of the American Academy of Pediatrics (AAP), Neonatal Resuscitation Steering Committee (NRP). Views expressed in this manuscript are those of authors and do not reflect the official position of AAP/NRP.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Sankaran, D., Molloy, E.J. & Lakshminrusimha, S. Is epinephrine effective during neonatal resuscitation?. Pediatr Res 93, 466–468 (2023). https://doi.org/10.1038/s41390-022-02411-2