We would like to share ideas on the publication, “Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19”.1 Due to its immune-modulatory effect, Zeidan et al. indicated that vitamin D insufficiency may be a modifiable risk factor for coronavirus disease 2019 (COVID-19) in children and adolescents. Our investigation on the VDR FokI polymorphism in Caucasian children and adolescents with COVID-19 is, as far as we are aware, the first of its kind. Both vitamin D insufficiency and the VDR FokI polymorphism may be independent risk factors for Egyptian children and adolescents’ susceptibility to COVID-19.1 In this study, the impact of a polymorphism is examined. The genetic component investigated in this article may or may not have an effect on COVID-19 infection. We both agree that the underlying genetic component being studied may be connected to COVID-19 infection. However, a number of genetic variants have been connected to COVID-19 infection. The interferon-gamma R1 polymorphism and the asthma 17q21 polymorphism are two examples of gene polymorphisms.2,3 The ramifications of unanticipated, potentially puzzling genetic variations should be the subject of future study.
Zeidan, N. M. S. et al. Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19. Pediatr. Res. https://doi.org/10.1038/s41390-022-02275-6 (2022).
Varahram, M. et al. Correlation of single-nucleotide polymorphism at interferon-gamma R1 (at position − 56) in positive purified protein derivative health workers with COVID-19 infection. Int. J. Mycobacteriol. 11, 318–322 (2022).
Mungmunpuntipantip, R. & Wiwanitkit, V. Asthma 17q21 polymorphism and risk of COVID-19 in children: correspondence. Pediatr. Pulmonol. https://doi.org/10.1002/ppul.26120 (2022).
The authors declare no competing interests.
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Mungmunpuntipantip, R., Wiwanitkit, V. Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19: correspondence. Pediatr Res 93, 1110 (2023). https://doi.org/10.1038/s41390-022-02348-6