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Neonatal hyperbilirubinemia and bilirubin neurotoxicity: what can be learned from the database analysis?

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  1. Qattea, I., Farghaly, M. A. A., Elgendy, M., Mohamed, M. A. & Aly, H. Neonatal hyperbilirubinemia and bilirubin neurotoxicity in hospitalized neonates: analysis of the US Database. Pediatr. Res. (2021).

    Article  PubMed  Google Scholar 

  2. Brooks, J. C., Fisher-Owens, S. A., Wu, Y. W., Strauss, D. J. & Newman, T. B. Evidence suggests there was not a ‘resurgence’ of kernicterus in the 1990s. Pediatrics 127, 672–679 (2011).

    Article  Google Scholar 

  3. Hansen, T. W. R. et al. Reversibility of acute intermediate phase bilirubin encephalopathy. Acta Paediatr. 98, 1689–1694 (2009).

    Article  Google Scholar 

  4. Harris, M. C., Bernbaum, J. C., Polin, J. R., Zimmerman, R. & Polin, R. A. Developmental follow-up of breastfed term and near-term infants with marked hyperbilirubinemia. Pediatrics 107, 1075–1080 (2001).

    CAS  Article  Google Scholar 

  5. Okolie, F., South-Paul, J. E. & Watchko, J. F. Combating the hidden health disparity of kernicterus in Black infants: a review. JAMA Pediatr. 174, 1199–1205 (2020).

    Article  Google Scholar 

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M.-C.C. drafted the article; all authors designed the article, interpreted the data, revised it critically for important intellectual content, and approved the final version to be published.

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Correspondence to Marie-Coralie Cornet.

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Cornet, MC., Kemper, A.R., Maisels, M.J. et al. Neonatal hyperbilirubinemia and bilirubin neurotoxicity: what can be learned from the database analysis?. Pediatr Res (2022).

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