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Hemodynamic dysfunction in neonatal sepsis


Cardiovascular disturbances are a frequent occurrence in neonatal sepsis. Preterm and term infants are particularly vulnerable due to the unique features of their cardiovascular function and reserve, compared to older children and adults. The clinical manifestations of neonatal sepsis are a product of the variable inflammatory pathways involved (warm vs. cold shock physiology), developmental state of the cardiovascular system, and hormonal responses. Targeted neonatal echocardiography has played an important role in advancing our knowledge, may help delineate specific hemodynamic phenotypes in real-time, and supports an individualized physiology-based management of sepsis-associated cardiovascular dysfunction.


Cardiovascular dysfunction is a common sequela of sepsis. This review aims to highlight the pathophysiological mechanisms involved in hemodynamic disturbance in neonatal sepsis, provide insights from targeted neonatal echocardiography-based clinical studies, and suggest its potential incorporation in day-to-day management.

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Fig. 1: Hemodynamic considerations among preterm infants with sepsis.
Fig. 2: Management of suspected late-onset sepsis and septic shock.


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A.K. and A.J. both conceived and designed the review. A.K. drafted the manuscript and A.J. revised it critically. Both A.K. and A.J. approve the final version as submitted.

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Correspondence to Ashraf Kharrat.

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Kharrat, A., Jain, A. Hemodynamic dysfunction in neonatal sepsis. Pediatr Res (2021).

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