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Disarray in the perinatal management of neonatal abstinence syndrome

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References

  1. 1.

    Degenhardt, L. et al. Global burden of disease attributable to illicit drug use and dependence: findings from the global burden of disease study 2010. Lancet 382, 1564–1574 (2013).

    Article  Google Scholar 

  2. 2.

    Faherty, L. J., Matone, M., Passarella, M. & Lorch, S. Mental health of mothers of infants with neonatal abstinence syndrome and prenatal opioid exposure. Mat. Child Health J. 22, 841–848 (2018).

    Article  Google Scholar 

  3. 3.

    Benningfield, M. M. et al. Co-occurring psychiatric symptoms are associated with increased psychological, social, and medical impairment in opioid dependent pregnant women. Am. J. Addict. 19, 416–421 (2010).

    Article  Google Scholar 

  4. 4.

    Wachman, E. M. et al. The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome. J. Addict. Med. 5, 293–299 (2011).

    Article  CAS  Google Scholar 

  5. 5.

    Grigoriadis, S. et al. The effect of prenatal antidepressant exposure on neonatal adaptation: a systematic review and meta-analysis. J. Clin. Psychiatry 74, e309–e320 (2013).

    Article  Google Scholar 

  6. 6.

    Huybrechts, K. F. et al. Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: a cohort study. BMJ 358, J33266 (2017).

    Google Scholar 

  7. 7.

    Bakhireva, L. N. et al. Severity of neonatal opioid withdrawal syndrome with prenatal exposure to serotonin reuptake inhibitors. Pediatr Res. (2021). Epub ahead of print.

  8. 8.

    Salisbury, A. L. et al. The roles of maternal depression, serotonin reuptake inhibitor treatment, and concomitant benzodiazepine use on infant neurobehavioral functioning over the first postnatal month. Am. J. Psychiatry 173, 147–157 (2016).

    Article  Google Scholar 

  9. 9.

    Lester, B. M. & Tronick, E. Z. History and description of the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Pediatrics 113, 634–640 (2004).

    PubMed  Google Scholar 

  10. 10.

    Flannery, T. et al. Neonatal Abstinence Syndrome Severity Index predicts 18-month neurodevelopmental outcome in neonates randomized to morphine or methadone. J. Pediatr. 227, 101–107 (2020).

    Article  CAS  Google Scholar 

  11. 11.

    Liu, J. et al. Neonatal neurobehavior predicts medical and behavioral outcome. Pediatrics 125, e90–e98 (2010).

    Article  Google Scholar 

  12. 12.

    Haapakoski, R., Mathieu, J., Ebmeier, K. P., Alenius, H. & Kivimaki, M. Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav. Immun. 49, 206–215 (2015).

    Article  CAS  Google Scholar 

  13. 13.

    Leff-Gelman, P. et al. The immune system and the role of inflammation in perinatal depression. Neurosci. Bull. 32, 398–420 (2016).

    Article  CAS  Google Scholar 

  14. 14.

    Seth, S., Lewis, A. J. & Galbally, M. Perinatal maternal depression and cortisol function in pregnancy and the postpartum period: a systematic literature review. BMC Pregnancy Childbirth 16, 124 (2016).

    Article  CAS  Google Scholar 

  15. 15.

    Rodriguez, N., Vining, M. & Bloch-Salisbury, E. Salivary cortisol levels as a biomarker for severity of withdrawal in opioid-exposed newborns. Pediatr. Res. 87, 1033–1038 (2020).

    Article  CAS  Google Scholar 

  16. 16.

    Conradt, E., Lester, B. M., Appleton, A. A., Armstrong, D. A. & Marsit, C. J. The roles of DNA methylation of NR3C1 and 11b-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior. Epigenetics 8, 1321–1329 (2013).

    Article  CAS  Google Scholar 

  17. 17.

    Gluckman, P. D., Hanson, M. A., Cooper, C. & Thornburg, K. L. Effect of in utero and early-life conditions on adult health and disease. N. Engl. J. Med. 359, 61–73 (2008).

    Article  CAS  Google Scholar 

  18. 18.

    Ostlund, B. D. et al. Maternal mindfulness during pregnancy predicts newborn neurobehavior. Dev. Psychobiol. 63, e22131 (2021).

    Article  Google Scholar 

  19. 19.

    Chin Foo, C. A., Dansereau, L. M., Hawes, K., Oliveira, E. L. & Lester, B. M. Improving the assessment of neonatal abstinence syndrome. Children 8, 685 (2021).

    Article  Google Scholar 

  20. 20.

    Patrick, S. W., Kaplan, H. C., Passarella, M., Davis, M. M. & Lorch, S. A. Variation in treatment of neonatal abstinence syndrome in US Children’s Hospitals, 2004-2011. J. Perinatol. 34, 867–872 (2014).

    Article  CAS  Google Scholar 

  21. 21.

    Young, W. et al. Site-level variation in the characteristics and care of infants with neonatal opioid withdrawal. Pediatrics 147, e2020008839 (2021).

    Article  Google Scholar 

  22. 22.

    Jansson, L. M. & Velez, M. L. Optimal care for NAS: Are we moving in the wrong direction? Hosp. Pediatr. 9, 655–658 (2019).

    Article  Google Scholar 

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B.M.L. contributed to reviewing the manuscript cited in the Commentary, both authors contributed to the drafting of the Commentary, and final review and edits of the Commentary.

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Correspondence to Barry M. Lester.

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Lester, B.M., Davis, J.M. Disarray in the perinatal management of neonatal abstinence syndrome. Pediatr Res (2021). https://doi.org/10.1038/s41390-021-01848-1

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