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Addressing drug overdose deaths in pediatrics: Where do we go from here?

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  1. 1.

    Hedegaard, H., Miniño, A. M. & Warner, M. Drug overdose deaths in the United States, 1999–2019. NCHS Data Brief. 394, 1–8 (2020).

  2. 2.

    Ahmad, F. B., Rossen, L. M. & Sutton, P. Provisional Drug Overdose Death Counts (National Center for Health Statistics, 2020).

  3. 3.

    Centers for Disease Control and Prevention. 2019 Annual Surveillance Report of Drug-Related Risks and Outcomes—United States Surveillance Special Report (Centers for Disease Control and Prevention, US Department of Health and Human Services, accessed 19 August 2020);

  4. 4.

    Gaither, J. R., Shabanova, V. & Leventhal, J. M. US National Trends in Pediatric Deaths From Prescription and Illicit Opioids, 1999-2016. JAMA Netw. Open. 1, e186558 (2018).

    Article  Google Scholar 

  5. 5.

    Kelly, B. C., Vuolo, M. & Frizzell, L. C. Pediatric drug overdose mortality: contextual and policy effects for children under 12 years. Pediatr Res. (2021).

  6. 6.

    Mattson, C. L. et al. Trends and geographic patterns in drug and synthetic opioid overdose deaths - United States, 2013-2019. Morb. Mortal. Wkly Rep. 70, 202–207 (2021).

    Article  Google Scholar 

  7. 7.

    Gagne, J. J., He, M. & Bateman, B. T. Trends in opioid prescription in children and adolescents in a commercially insured population in the United States, 2004-2017. JAMA Pediatr. 173, 98–99 (2018).

  8. 8.

    Schieber, L. Z. et al. Trends and patterns of geographic variation in opioid prescribing practices by state, United States, 2006-2017. JAMA Netw. Open. 2, e190665 (2019).

    Article  Google Scholar 

  9. 9.

    C.S. Mott Children’s Hospital. National Poll on Children’s Health. University of Michigan. 26, (2016).

  10. 10.

    Lim, J. K., Earlywine, J. J., Bagley, S. M., Marshall, B. D. L. & Hadland, S. E. Polysubstance involvement in opioid overdose deaths in adolescents and young adults, 1999-2018. JAMA Pediatr. 175, 194–196 (2021).

    Article  Google Scholar 

  11. 11.

    Roehler, D. R., Olsen, E. O., Mustaquim, D. & Vivolo-Kantor, A. M. Suspected nonfatal drug-related overdoses among youth in the US: 2016-2019. Pediatrics 147, e2020003491 (2021).

  12. 12.

    Yin, S. Malicious use of pharmaceuticals in children. J. Pediatr. 157, 832–836.e831 (2010).

    Article  Google Scholar 

  13. 13.

    Gauthey, M., Capua, M., Brent, J. & Finkelstein, Y. Poisoning with malicious or criminal intent: characteristics and outcome of patients presenting for emergency care. Clin. Toxicol. 57, 628–631 (2019).

    CAS  Article  Google Scholar 

  14. 14.

    Shepherd, G. & Ferslew, B. C. Homicidal poisoning deaths in the United States 1999–2005. Clin. Toxicol. 47, 342–347 (2009).

    Article  Google Scholar 

  15. 15.

    Wells, K. Substance abuse and child maltreatment. Pediatr. Clin. N. Am. 56, 345–362 (2009).

    Article  Google Scholar 

  16. 16.

    Kurani, S. et al. Place, poverty and prescriptions: a cross-sectional study using Area Deprivation Index to assess opioid use and drug-poisoning mortality in the USA from 2012 to 2017. BMJ Open. 10, e035376 (2020).

    Article  Google Scholar 

  17. 17.

    Hamilton, L., Davis, C. S., Kravitz-Wirtz, N., Ponicki, W. & Cerdá, M. Good Samaritan laws and overdose mortality in the United States in the fentanyl era. Int. J. Drug Policy 97, 103294 (2021).

    Article  Google Scholar 

  18. 18.

    Cerdá, M. et al. Measuring relationships between proactive reporting state-level prescription drug monitoring programs and county-level fatal prescription opioid overdoses. Epidemiology 31, 32–42 (2020).

    Article  Google Scholar 

  19. 19.

    Martins, S. S. et al. Prescription drug monitoring programs operational characteristics and fatal heroin poisoning. Int. J. Drug Policy 74, 174–180 (2019).

    Article  Google Scholar 

  20. 20.

    Prescription Drug Abuse Policy System. Center for Public Health Law Research at the Temple University Beasley School of Law. (2021).

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Dr. Renny was supported by the T32HS026120 grant from the Agency for Healthcare Research and Quality.

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Correspondence to Madeline H. Renny.

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Renny, M.H., Cerdá, M. Addressing drug overdose deaths in pediatrics: Where do we go from here?. Pediatr Res (2021).

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