Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

INVITED COMMENTARY

Definitions of necrotizing enterocolitis: What are we defining and is machine learning the answer?

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Brawanski, A. On the myth of the Edwin Smith papyrus: is it magic or science? Acta Neurochir. 154, 2285–2291 (2012).

    Article  Google Scholar 

  2. Bell, M. J. et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann. Surg. 187, 1–7 (1978).

    Article  CAS  Google Scholar 

  3. Walsh, M. C. & Kliegman, R. M. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr. Clin. N. Am. 33, 179–201 (1986).

    Article  CAS  Google Scholar 

  4. Kliegman, R. M. & Fanaroff, A. A. Neonatal necrotizing enterocolitis in the absence of pneumatosis intestinalis. Am. J. Dis. Child 136, 618–620 (1982).

    CAS  PubMed  Google Scholar 

  5. Di Napoli, A. et al. Inter-observer reliability of radiological signs of necrotising enterocolitis in a population of high-risk newborns. Paediatr. Perinat. Epidemiol. 18, 80–87 (2004).

    Article  Google Scholar 

  6. Liu, H. & Turner, T. W. S. Allergic colitis with pneumatosis intestinalis in an infant. Pediatr. Emerg. Care 34, e14–e15 (2018).

    Article  Google Scholar 

  7. Robinson, A. E., Grossman, H. & Brumley, G. W. Pneumatosis intestinalis in the neonate. Am. J. Roentgenol. 120, 333–341 (1974).

    Article  CAS  Google Scholar 

  8. Patel, R. M., Ferguson, J., McElroy, S. J., Khashu, M. & Caplan, M. S. Defining necrotizing enterocolitis: current difficulties and future opportunities. Pediatr. Res. 88, 10–15 (2020).

    Article  Google Scholar 

  9. Lueschow, S. R., Boly, T. J., Jasper, E., Patel, R. M. & McElroy, S. J. A critical evaluation of current definitions of necrotizing enterocolitis. Pediatr. Res. https://doi.org/10.1038/s41390-021-01570-y (2021).

    Article  PubMed  Google Scholar 

  10. Beam, K. S., Lee, M., Hirst, K., Beam, A. & Parad, R. B. Specificity of International Classification of Diseases codes for bronchopulmonary dysplasia: an investigation using electronic health record data and a large insurance database. J. Perinatol. 41, 764–771 (2021).

    Article  Google Scholar 

  11. Lohr, S. Whatever happened to IBM’s Watson? The Boston Globe (7 July 2021).

  12. Roberts, M. et al. Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans. Nat. Mach. Intell. 3, 199–217 (2021).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Camilia R. Martin.

Ethics declarations

Competing interests

Dr. Martin serves on the advisory boards of The NEC Society, LactaLogics, Inc., and Plakous Therapeutics, Inc. Dr. Martin has consulted with Mead Johnson Nutrition and has a research grant from Mead Johnson Foundation. None of these entities had a role in the writing of this article. 

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Martin, C.R. Definitions of necrotizing enterocolitis: What are we defining and is machine learning the answer?. Pediatr Res 91, 488–489 (2022). https://doi.org/10.1038/s41390-021-01687-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41390-021-01687-0

Search

Quick links