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Pulmonary hypertension in bronchopulmonary dysplasia

Abstract

Bronchopulmonary dysplasia (BPD) is a major complication in prematurely born infants. Pulmonary hypertension (PH) associated with BPD (BPD-PH) is characterized by alveolar diffusion impairment, abnormal vascular remodeling, and rarefication of pulmonary vessels (vascular growth arrest), which lead to increased pulmonary vascular resistance and right heart failure. About 25% of infants with moderate to severe BPD develop BPD-PH that is associated with high morbidity and mortality. The recent evolution of broader PH-targeted pharmacotherapy in adults has opened up new treatment options for infants with BPD-PH. Sildenafil became the mainstay of contemporary BPD-PH therapy. Additional medications, such as endothelin receptor antagonists and prostacyclin analogs/mimetics, are increasingly being investigated in infants with PH. However, pediatric data from prospective or randomized controlled trials are still sparse. We discuss comprehensive diagnostic and therapeutic strategies for BPD-PH and briefly review the relevant differential diagnoses of parenchymal and interstitial developmental lung diseases. In addition, we provide a practical framework for the management of children with BPD-PH, incorporating the modified definition and classification of pediatric PH from the 2018 World Symposium on Pulmonary Hypertension, and the 2019 EPPVDN consensus recommendations on established and newly developed therapeutic strategies. Finally, current gaps of knowledge and future research directions are discussed.

Impact

  • PH in BPD substantially increases mortality. Treatment of BPD-PH should be conducted by an interdisciplinary team and follow our new treatment algorithm while still kept tailored to the individual patient.

  • We discuss recent developments in BPD-PH, make recommendations on diagnosis, monitoring and treatment of PH in BPD, and address current gaps of knowledge and potential research directions.

  • We provide a practical framework, including a new treatment algorithm, for the management of children with BPD-PH, incorporating the modified definition and classification of pediatric PH (2018 WSPH) and the 2019 EPPVDN consensus recommendations on established and newly developed therapeutic strategies for BPD-PH.

Introduction

Bronchopulmonary dysplasia (BPD) represents a major cardiopulmonary complication in survivors of premature birth. The incidence of BPD is on the rise despite/because of the advances in neonatal intensive care.1 Besides impaired proximal airway and bronchoalveolar development, BPD is often associated with pulmonary vascular disease (PVD) and secondary pulmonary hypertension (PH). PH associated with BPD (BPD-PH) is characterized by abnormal vascular remodeling and rarefication of the pulmonary vasculature (vascular growth arrest),2 leading to increased pulmonary vascular resistance (PVR) and right heart failure. About 25% of infants with moderate to severe BPD develop PH3,4 that affects heart and lungs, greatly increasing mortality (47% of BPD infants die 2 years after diagnosis of PH).5,6,7

Compared to BPD without PH, BPD-PH is associated with suboptimal somatic growth and neurodevelopmental outcome,8,9 and higher rates of tracheostomy, increased use of supplemental oxygen, feeding problems, and frequent hospital admissions.10 Young adults born preterm (very low birth weight ≤1500 g; average gestational age 28 weeks) are at increased risk for PVD, PH, and right ventricular (RV) dysfunction.11

The increased survival of even the most immature infants makes infants with BPD-PH an ever-growing population among pediatric PH patients, requiring highly specialized care. Nevertheless, there is still a paucity of published data supporting the current management of children with BPD-PH.

In this article, we briefly review evolving concepts on the pathobiology of BPD-PH. We further discuss comprehensive diagnostic strategies, including the differential diagnosis of rather rare parenchymal and interstitial developmental lung diseases associated with PH. We provide a practical framework for the clinical management of children with BPD-PH, including established and newly developed therapeutic strategies, based on the 2018 World Symposium on Pulmonary Hypertension, and the 2019 updated consensus recommendations of the European Pediatric Pulmonary Vascular Disease Network (EPPVDN).12,13 Finally, we discuss current gaps of knowledge and potential future research directions.

Definition and classifications of pediatric PH

The WSPH 2018 modified the definition and classification of PH presented in the “2015 ESC/ERS Guidelines.”13,14 Specifically, the lower limit of normal mean pulmonary arterial pressure (mPAP) was decreased from 24 to 20 mmHg.15 In adults, even mildly elevated mPAP values (20–24 mmHg, prognostic threshold 17 mmHg) were found to be independent predictors of poor survival.16 For consistency, this new definition of PH was also used in the pediatric WSPH 2018 document13 and the current 2019 EPPVDN guidelines,12 although the cut-off mPAP >20 mmHg remains arbitrary for children (Table 1). The Pulmonary Vascular Research Institute’s (PVRI) Panama Classification divided pulmonary hypertensive vascular disease (PHVD = PVD + PH) into 10 main categories, including BPD-PH, and more than 100 subcategories (2011).17 It should be noted that due to the physiologic postnatal elevation and subsequent decline of PVR after birth, the new mPAP cut-off value of 20 mmHg only applies to infants beyond 3 months of age. However, the aforementioned definition of PH does not specify whether chronological or corrected age should be used in preterm infants. Furthermore, prognostic studies on the relevance of borderline-elevated mPAP in older infants are currently lacking. Due to this ambiguity, BPD patients at risk for or with confirmed PH must be evaluated and cared for by a multidisciplinary team of PH specialists, including neonatologists, pediatric cardiologists, and pulmonologists, with experience in the care of infants with PH.12,18,19

Table 1 Developmental lung diseases associated with pulmonary hypertension.

Current concepts of the pathobiology of BPD-PH

PH associated with BPD mainly develops in survivors of extreme preterm birth as a result of incomplete lung development (abnormal alveolarization), postnatal hyperoxia-/hypoxia-triggered vascular remodeling, and the rarefication of pulmonary blood vessels (vascular growth arrest).2 Dysbalanced TGFβ/BMP20 and VEGF signaling in BPD are pathobiological hallmarks of BPD-PH.2 Risk factors for BPD include placental anomalies, extreme prematurity, very low birth weight, intra-uterine growth restriction, perinatal infections, oxygen toxicity, and mechanical ventilation.2,21 While the precise mechanisms of PH associated with BPD are still unknown, it is likely they involve insults such as inflammation and endothelial dysfunction, perpetuated through alveolar hypoxia.2,21 In older infants, a cycle of progressive respiratory insufficiency, hypoxia, and compromised pulmonary perfusion aggravates PH, contributing to the increased mortality observed in BPD-PH infants.

Diagnosis of BPD and BPD-PH

Clinical suspicion of BPD-PH should be raised in every infant with a history of prematurity who requires supplemental oxygen and/or invasive or non-invasive respiratory support. Traditionally, BPD is defined clinically as supplemental oxygen use either at a corrected age of 36 gestational weeks (p.m.) or after 28 days of postnatal life in infants born <32 weeks of gestational age.22 However, this definition has recently been challenged and a new definition of BPD was proposed that includes infants on any form of respiratory support (such as high-flow nasal cannula) at 36 corrected weeks (p.m.), even in the absence of supplemental oxygen use.23 The significance of this new, alternative BPD definition for the frequency and morbidity of BPD-PH still needs to be investigated, and has not been used yet for this review article. In any case, PH/PHVD might occur before the formal diagnosis of BPD can be made. Indeed, echocardiographic screening may help identify infants at risk for BPD-PH as early as 7 days of life.4

While BPD-specific changes are detected on conventional chest X-ray, the initial assessment of suspected PH is based on transthoracic echocardiography (TTE) (Fig. 1). Here, one should not rely on a single TTE parameter, but follow a multiparametric approach. Even with a history of immaturity, certain (rare) interstitial or parenchymal developmental lung diseases that can mimic BPD/BPD-PH must be included in the differential diagnosis (Table 1). Cardiac anomalies should be ruled out as these might affect therapy: for example, the presence of hemodynamically significant cardiovascular post-tricuspid shunts, such as large ventricular septal defects, often preclude the use of pulmonary vasodilators due to an aggravation of the shunt volume resulting from decreased PVR.12

Fig. 1: Management of pulmonary hypertension in bronchopulmonary dysplasia.
figure1

BPD—bronchopulmonary dysplasia; ERA—endothelin receptor antagonist; iNO—inhaled nitric oxide; LV—left ventricle; RV—right ventricle; PAAT—pulmonary artery acceleration time; PH—pulmonary hypertension; S/D ratio—systolic to diastolic duration ratio; TAPSE—tricuspid annular posterior systolic excursion; TRV—tricuspid regurgitation velocity. *Screening for pulmonary hypertension by transthoracic echocardiography is indicated (1) if severe respiratory compromise is present in any preterm infant <28 weeks of gestation, (2) in any infant with established BPD at corrected age of 36 weeks gestation (p.m.) and before discharge, (3) in any infant with prolonged oxygen requirement, poor growth, and unsatisfactory clinical improvement. **Cardiac catheterization should be considered before (i) introduction of a second PH-specific medication and is advised if PH worsens under dual therapy or if unsatisfactory treatment response is seen in any infant with PH at a corrected postnatal age of >3 months.

Echocardiography for diagnosis and monitoring of PH

TTE is an important diagnostic and monitoring modality.12,24,25,26,27 Screening for PH by TTE is indicated (1) if severe respiratory compromise is present in any preterm infant <28 weeks of gestation, (2) in any infant with established BPD at corrected age of 36 weeks gestation (p.m.) and before discharge, (3) in any infant with prolonged oxygen requirement, poor growth, unsatisfactory clinical improvement,12 and has also been suggested at 7 days of life to identify infants at risk for BPD-PH.4 Comprehensive TTE allows for complete initial assessment of cardiovascular anatomy and may also confirm RV pressure elevation through the measurement of the maximal velocity of the tricuspid regurgitation (TR) jet by continuous wave Doppler; TTE can detect impaired RV systolic function through qualitative assessment in several views, and quantitatively by means of a reduced age-related tricuspid annular plane systolic excursion as surrogate of longitudinal systolic RV function.12 Of note, TTE variables have different age-related reference ranges and variable impact on the accuracy of the diagnosis “PH” in children vs. adults, especially in young infants.24 The presence of a hemodynamically significant post-tricuspid shunt makes TTE estimation of PAP elevation less accurate.28

The relevant non-invasive imaging risk variables currently evaluated for infants and young children with PH,12 including those with BPD-PH, are listed in Table 2.

Table 2 Echocardiographic determinants of PH risk in infants.

Magnetic resonance imaging and chest computed tomography

Magnetic resonance imaging (MRI) and computed tomography (CT) have become essential non-invasive imaging modalities in suspected or confirmed PH.12 MRI offers the ability to assess pulmonary and systemic blood flow, pulmonary regional perfusion, PA and aortic diameters, (bi-) ventricular cardiac function, and myocardial tissue characteristics.29 More recently, lung MRI (e.g., TWIST, time-resolved angiography with stochastic trajectories) was introduced to assess lung perfusion in PHVD.30,31 A recent study on MRI in BPD-PH revealed that the pulmonary artery to aorta ratio (PA/AO) increased with BPD severity. An increased PA/AO and MR-derived LV end-systolic eccentricity index (MR-LVEI) were associated with increased length of stay and duration of respiratory support in BPD infants.31 Both increased PA/AO ratio and MR-LVEI were associated with PH therapy during hospitalization and at discharge. The primary role of chest CT is to detect lung parenchymal disorders, thromboembolic disease, and vascular abnormalities, such as pulmonary vein stenosis, which may be causally linked to evident PH. The key role of chest imaging, including newer MRI techniques in differentiating interstitial and parenchymal developmental lung disease has been discussed elsewhere.32 The significant risk of sedation/general anesthesia in PH patients need to be balanced against the potential gain of information of MRI or CT studies, and their impact on the future therapy of the individual PH patient.12

Diagnostic cardiac catheterization in suspected or confirmed BPD-PH

Cardiac catheterization is rarely necessary to make the diagnosis of BPD-PH early on. Although cardiac catheterization with acute pulmonary vasoreactivity testing (AVT) generally is recommended in pediatric PH prior to the initiation of pulmonary vasodilator therapy,11,12,13 exceptions may be made when the risk of the cardiac catheterization outweighs the potential benefits; for instance, severe hemodynamic instability (premature infants) or evidence of systemic vasculopathies. However, cardiac catheterization for the diagnosis and assessment of BPD-PH should be considered before introduction of a second PH-targeted medication; cardiac catheterization is advised if PH worsens under dual PH-targeted therapy or if an unsatisfactory response to PH-targeted pharmacotherapy is seen in any infant with PH at a corrected postnatal age of >3 months (Fig. 1).13 Additional indications include concern for vascular abnormalities (e.g., pulmonary vein stenosis),33 other features of an atypical response to therapy, and/or failure to thrive.34

A systematic cardiac catheterization protocol for pediatric PH is available.12 However, the complexity of pediatric PH/PVD often requires individualized adaptations of these recommendations. A recent study found that AVT may aid in the assessment of disease severity and management of BPD-PH. In this cohort of 26 infants with BPD, 35% had positive AVT, which was associated with better long-term outcomes. AVT also distinguished higher from lower risk PH in infants with BPD better than baseline pulmonary hemodynamics.35 Others found that the severity of lung disease as assessed by impaired oxygenation at cardiac catheterization did not correlate with mortality while the presence of pulmonary vein stenosis was associated with death.33

Biomarkers

Blood biomarker concentrations contribute to tailoring longitudinal medical care of PH patients.12 Brain natriuretic peptide (BNP) and its N-terminal cleavage product (NT-proBNP) are secreted by cardiomyocytes in response to ventricular wall stress due to pressure overload and/or volume expansion. Both biomarkers exhibit similar relative stress-induced release and age dependency, but NT-proBNP has the longer half-life (118 vs. 18 min). In a meta-analysis of 25 small-scale pediatric studies, serum NT-proBNP was identified as significant prognostic factor in pediatric PH and suggested to aid in the longitudinal assessment of patients36 (reference values of NTproBNP-BNP37). Recent studies have also shown the applicability of serum NT-proBNP as a suitable biomarker in infants with BPD-PH.38,39,40 Based on our experience, especially in infants, absolute values of NT-proBNP have a high inter-individual variance, are strongly dependent on postnatal and gestational age, and thus have limited value in establishing the diagnosis or severity of PH, especially in young infants. However, longitudinal assessment of NT-proBNP in combination with echocardiography is very useful to assess disease progression and/or response to treatment.41,42,43,44

Meanwhile, additional biomarkers are under consideration and may contribute to future PH management.12,40

Treatment

Supportive measures

Supplemental oxygen should be supplied when target oxygen saturations are >93% for infants with suspected and >95% for infants with proven PH (Fig. 1).12 Maximizing non-invasive respiratory support as much as possible in order to avoid mechanical ventilation and therefore aggravation of lung injury is advisable. However, atelectasis causes an increased ventilation/perfusion mismatch and local hypoxic vasoconstriction, and thus needs to be avoided. In addition, treatment with diuretics, that is, hydrochlorothiazide and spironolactone may be considered in infants with severe BPD.12 However, diuretic therapy in preterm infants remains controversial, given its negative impact on growth and the risk for metabolic bone disease. Thus, indications and duration of diuretic treatment should be discussed in a multidisciplinary team, involving cardiologists, neonatologists, pulmonologists, and nutritionists. Infants with severe BPD have higher caloric requirements, which should be accounted for in their nutritional plans (up to 160 kcal/kg). Infants with BPD-PH are prone to a sudden elevation of PVR when undergoing stressful procedures (“PH crisis”) and often require sufficient sedation or even analgesia/relaxation before such procedures are performed in an intensive care setting. Administration of inhaled nitric oxide and phosphodiesterase-3 inhibitors, such as milrinone, which are frequently used for acute treatment of PH in infants (e.g., in PPHN or acute deterioration of BPD-PH), are beyond the scope of this review and discussed elsewhere.12

Pharmacotherapy

General considerations

The overall goal of therapy for PH patients, adult or pediatric, is (1) to induce pulmonary arterial vasodilation, (2) to pressure unload and support the RV, (3) to avoid coronary ischemia and heart failure, (4) improve clinical outcomes and quality of life, and (5) to improve signs and symptoms, and thus the aggravation of PH.12,14,45,46,47 Of note, especially oral pulmonary vasodilator therapy may amplify ventilation and perfusion mismatch in any type of PH, especially in the setting of lung disease.

Regardless of a patient’s age or type of PH (group 1–5 PH),15 PH-targeted therapy currently focuses on three main molecular pathways: the nitric oxide pathway, the endothelin pathway, and the prostacyclin pathway (Table 3). While only two drugs have so far been approved by the regulatory European Medicines Agency (EMA) for pediatric patients with PAH, that is, sildenafil (body weight ≥8 kg and >1 year old) and bosentan (age >1 year), only bosentan has been approved by the Food and Drug Administration (FDA) for chronic use in PH children > 3 years of age. However, both sildenafil and bosentan are frequently used for acute and long-term treatment of infants with BPD-PH (Fig. 1).41,42 In the absence of randomized clinical trial data, use of PH-targeted medications in infants is based on expert opinion and experience, underlining the necessity of comprehensive evaluation in PH expert centers according to current international recommendations.12,48 The primary treatment goal for patients with PH associated with developmental lung diseases (group 3 PH)15 is to treat the underlying lung disease.12,48 However, BPD-PH patients are likely to benefit from vasodilator treatment.12,48,49 A recent, retrospective analysis showed clinical and echocardiographic improvements with a survival rate of 95% during a median follow-up time of 2 years in infants treated with PH-targeted therapy for BPD complicated by PH.42

Table 3 Pharmacotherapy of BPD-PH.

Pharmacotherapy to modify the nitric oxide pathway

Phosphodiesterase-5 (PDE5) inhibitors are the most commonly employed drugs acting on the nitric oxide (NO) pathway, namely sildenafil and tadalafil. PDE5 inhibitors inhibit primarily PDE5 (NO/cGMP pathway), thus inducing vasodilation through vascular smooth muscle cell relaxation, and also exhibit anti-proliferative effects.50 STARTS-1 and its extension phase, STARTS-2,51 were the first pediatric randomized, placebo-controlled clinical trials in PAH. The STARTS study demonstrated improvement in secondary outcomes among those PH patients on medium- or high-dose sildenafil, including functional class and PVR. Controversially, the STARTS trial detected an increase in mortality among those subjects receiving high-dose sildenafil vs. placebo group, which in 2013 led to a warning of the EMA not to use higher doses, and rejection of approval by the FDA. Nevertheless, sildenafil is—by most centers and experts—regarded as a safe and efficacious first-of-choice drug for PH/PVD in children, and its widespread use and recommendation in formal guidelines continues.12,42 Sildenafil at standard dose should be considered in children with BPD-PH as improvements of clinical status and PAP have been demonstrated for oral sildenafil therapy.41 Tadalafil is reported to be widely used in North America due to its reduced dosing frequency, compared to sildenafil. Common to all PDE5 inhibitors, gastroesophageal reflux is an often reported unwanted effect that is also highly relevant to neonates and infants.46 Riociguat is a novel oral agent with dual mode of action that acts in synergy with endogenous NO and directly stimulates soluble guanylyl cyclase, with only very limited pediatric experience.47

Pharmacotherapy to modify the endothelin pathway

Bosentan, an oral non-selective endothelin A- and B-receptor antagonist (ERA), counteracts the vasoconstrictive and mitogenic effects of endothelin-1 in PAH patients. Elevated liver aminotransferases may occur with bosentan use as a serious adverse event, but seem to be less frequent in children under 12 years than in adults and children ≥12 years of age (2.7% vs. 7.8%).52,53,54,55 Nevertheless, monthly liver enzyme and function testing should be performed in children receiving bosentan.12,14 ERA treatment may also be considered in BPD infants.12 Macitentan provides an alternative to bosentan that shows a more favorable safety profile (less liver toxicity, no teratogenicity). Macitentan has been studied in a small prospective pediatric study and was shown to be safe and efficacious as add-on therapy.44 Off-label use of macitentan also has been reported in BPD-PH patients.56 Of note, bosentan lowers circulating sildenafil levels, while the other two ERA, ambrisentan and macitentan, do not.12

Pharmacotherapy to modify the prostacyclin pathway: prostacyclin and prostacyclin analogs (PGI2 and PGI2 analogs; PCA)

Prostacyclin (PGI2) and its analogs activate the PGI2receptor (IP receptor) and lead to vasodilation, inhibit vascular smooth muscle cell proliferation, and have anti-inflammatory effects. PCAs were developed which facilitate intravenous, but also subcutaneous, inhaled, and more recently oral delivery routes.12 As with other pulmonary vasodilators, PGI2 or PCAs may have off-target effects prompting side effects, including headache, jaw pain, nausea, vomiting, abdominal pain, diarrhea, and flushing. Inhaled PGI2 or PCAs may cause airway hyperreactivity,57 in addition to headaches and flushing. However, the use of especially inhaled PCAs has been reported in infants, for example, inhaled iloprost might be used as monotherapy or as adjuvant.58 Selexipag is a new oral selective prostacyclin receptor (IP receptor) agonist, but not yet systematically studied in “BPD-PH”. The first prospective, pediatric multicenter study on PAH-combination therapy indicates that selexipag can be used safely even in small children (4–10 kg bodyweight), and that a positive drug response can be expected in half of the children treated with selexipag.43

Interventional and surgical procedures

In children with BPD, large left-to-right atrial or ventricular shunts are not well tolerated, and may be closed early if PVD is mild (i.e., no or only mild PVR elevation at cardiac catheterization).59 However, aorto-pulmonary connections (e.g., a patent ductus arteriosus, PDA) may facilitate decompressing a pressure-loaded RV in severe PH/PVD.12 Procedures for palliation of children with severe PH and RV failure include the creation of a right-to-left shunt with the aim to decompress the right heart and to increase cardiac output. These interventions decompress the right atrium only (balloon atrial septostomy, BAS) or the RV (reverse Potts shunt). While the interatrial shunt resulting from BAS only secures some cardiac output in critical supra-systemic PAP elevations, the “endogenous” reverse Potts shunt (e.g., through stenting of a small PDA) clearly decomprresses the RV and lowers RV pressure.

The resulting hemodynamic situation after both interventional procedures is similar to the physiology of Eisenmenger patients. In imminent RV failure, an existing PDA can be balloon-dilated and stented (endogenous Potts shunt), representing an elegant procedure to decompress a failing RV and may be considered in patients with supra-systemic PH refractory to any medical treatment, including combination PH-targeted therapy.12,60 Similarily, in acute deterioration, PGE1 may be used to keep the PDA open at the expense of hypoxemia in the lower half of the body.

Prevention of BPD-PH

Two recent studies on clinical risk factors for BPD-PH identified these to be similar to the risk factors known to be associated with BPD: extreme prematurity, mechanical ventilation, tracheostomy, tracheitis, intraventricular hemorrhage (grade ≥3) and systemic steroid use, hyperoxia, and inflammation/sepsis.61,62 Thus, preventive measures to decrease BPD frequency and severity are of pivotal importance in order to lower the BPD-PH burden among preterm infants. These preventive measures include, but are not limited to: less use of invasive mechanical ventilation and predominant use of non-invasive respiratory support strategies, minimally invasive surfactant application, avoidance of hyper- and hypoxia, caffeine, corticosteroids, and reduction of infections.63,64,65,66 Further research is required to determine the role of caffeine and corticosteroids on the developing pulmonary vasculature. The same is true for a possible contribution of a hemodynamically significant PDA (here: sole left-to-right shut) to PH and PVD in BPD infants. In addition, early biomarkers, detection, and treatment of PH + PVD might hold the potential to decrease BPD-PH disease severity (Table 4).

Table 4 Future research directions in BPD-PH.

Conclusions and future research directions

BPD-PH represents a significant burden to pediatric PH programs, but has been relatively understudied to date. The current wide ambiguity regarding optimal diagnosis, treatment, and monitoring of disease progression creates several high yield opportunities for study and practice improvement (Table 4). These include, but are not limited to: (1) comprehensive observational research cohort studies of the epidemiology of PH among high risk individuals with lung disease; (2) formal therapeutic trials incorporating PH-specific therapies in concert with traditional disease-specific approaches (e.g., oxygen and nutritional support); (3) novel therapies, including those directed at the underlying lung disease and those directed toward the pulmonary vasculature must be developed and studied, including modern oral combination pharmacotherapy; and, (4) studies designed to prevent and detect PH earlier among those with significant lung disease. Finally, cell-based therapies such as the use of mesenchymal stem cells (MSCs), MSC-conditioned media (cell media) or MSC extracellular vesicles/exosomes have shown promising preclinical results in reversing BPD-PH and several clinical trials are underway.67,68,69,70 A phase 1 study on the use of mesenchymal stem cell-derived extracellular vesicles in preterm neonates at high risk for BPD is underway (NCT03857841).

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Acknowledgements

This work was supported by the European Pediatric Pulmonary Vascular Disease Network (www.pvdnetwork.org). Dr. Hansmann receives financial support from the German Research Foundation (DFG; HA4348/2-2, HA4348/6-2 KFO311), and the Federal Ministry of Education and Research (BMBF ViP+ program 03VP08053; BMBF 01KC2001B). SK was supported in part by NIH grants R01 HL055454 and R01HL146128. Open access funding provided by Projekt DEAL.

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Hansmann, G., Sallmon, H., Roehr, C.C. et al. Pulmonary hypertension in bronchopulmonary dysplasia. Pediatr Res 89, 446–455 (2021). https://doi.org/10.1038/s41390-020-0993-4

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