Transforming growth factor-β1 (TGF-β1)/Smad signaling pathway. TGF-β1 can activate Smad 2/3 by binding to the membrane-bound TGF-β1 receptor (TβR). Thereafter, Smad 2/3 bound to Smad 4 enters the nucleus and regulates target gene transcription. Smad 7 can bind to the TβR and inhibit the activation of Smad signaling [1].
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Hu, D. et al. Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial–mesenchymal transition via the TGF-β/Smad signaling pathway. Pediatr. Res. https://doi.org/10.1038/s41390-019-0736-6 (2020).
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Hu, D., Zhang, D., Liu, B. et al. Insights Image for “Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial-mesenchymal transition via the TGF-β/Smad signaling pathway”. Pediatr Res 88, 336 (2020). https://doi.org/10.1038/s41390-020-0847-0
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DOI: https://doi.org/10.1038/s41390-020-0847-0
