Reply to “The use of gene expression as disease stratification tool of neonatal encephalopathy”

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Burgod, C., Thayyil, S. & Montaldo, P. The use of gene expression as a disease stratification tool of neonatal encephalopathy. Pediatr. Res. (2020).

  2. 2.

    Montaldo, P. et al. Whole blood gene expression reveals specific transcriptome changes in neonatal encephalopathy. Neonatology 115, 68–76 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Montaldo, P., Lally, P. J., Oliveira, V. & Thayyil, S. Hypothermic neuroprotection for neonatal encephalopathy in low- and middle-income countries: a new approach to an old problem. NeoReviews 19, e735–e741 (2018).

    Article  Google Scholar 

  4. 4.

    Balada, R. et al. Enquiring beneath the surface: can a gene expression assay shed light into the heterogeneity among newborns with neonatal encephalopathy? Pediatr. Res. 88, 451–458 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Bustin, S. A. et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55, 611–622 (2009).

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Ioannidis, J. P. et al. Repeatability of published microarray gene expression analyses. Nat. Genet. 41, 149–155 (2009).

    CAS  Article  Google Scholar 

  7. 7.

    Nair, J. & Kumar, V. H. S. Current and emerging therapies in the management of hypoxic ischemic encephalopathy in neonates. Children 5, 99 (2018).

    Article  PubMed  Google Scholar 

  8. 8.

    Graham, E. M., Everett, A. D., Delpech, J. C. & Northington, F. J. Blood biomarkers for evaluation of perinatal encephalopathy: state of the art. Curr. Opin. Pediatr. 30, 199–203 (2018).

    Article  PubMed  Google Scholar 

  9. 9.

    Song, J. et al. Extended solution gate OFET-based biosensor for label-free glial fibrillary acidic protein detection with polyethylene glycol-containing bioreceptor layer. Adv. Funct. Mater. 27, 1606506 (2017).

    Article  PubMed  Google Scholar 

  10. 10.

    Zheng, G. & Lieber, C. M. Nanowire biosensors for label-free, real-time, ultrasensitive protein detection. Methods Mol. Biol. 790, 223–237 (2011).

    CAS  Article  PubMed  Google Scholar 

Download references


This work was supported by a grant (PI08/1366) from the Instituto de Salud Carlos III cofounded by the European Regional Development Fund.

Author information




A.G.-A. and S.A. conceived and supervised the answer. R.B. wrote the answer and S.A. and A.G.-A. critically revised the manuscript. C.T. performed the statistical analysis. All authors reviewed the article for intellectual content and approved the manuscript.

Corresponding author

Correspondence to Alfredo Garcia-Alix.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Balada, R., Tebé, C., Alcántara, S. et al. Reply to “The use of gene expression as disease stratification tool of neonatal encephalopathy”. Pediatr Res (2020).

Download citation