Clinical Research Article | Published:

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Abstract

Background

The BabyLux device is a prototype optical neuro-monitor of cerebral oxygenation and blood flow for neonatology integrating time-resolved reflectance spectroscopy and diffuse correlation spectroscopy.

Methods

Here we report the variability of six consecutive 30 s measurements performed in 27 healthy term infants at rest. Poor data quality excluded four infants.

Results

Mean cerebral oxygenation was 59.6 ± 8.0%, with intra-subject standard deviation of 3.4%, that is, coefficient of variation (CV) of 5.7%. The inter-subject CV was 13.5%. Mean blood flow index was 2.7 × 10−8 ± 1.56 × 10−8 (cm2/s), with intra-subject CV of 27% and inter-subject CV of 56%. The variability in blood flow index was not reduced by the use of individual measures of tissue scattering, nor accompanied by a parallel variability in cerebral oxygenation.

Conclusion

The intra-subject variability for cerebral oxygenation variability was improved compared to spatially resolved spectroscopy devices, while for the blood flow index it was comparable to that of other modalities for estimating cerebral blood flow in newborn infants. Most importantly, the simultaneous measurement of oxygenation and flow allows for interpretation of the high inter-subject variability of cerebral blood flow as being due to error of measurement rather than to physiological instability.

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Acknowledgements

We would like to thank all collaborators in the BabyLux consortium and the parents of the infants included in the clinical investigation. This research was funded by the European Commission Competitiveness for Innovation Program (grant agreement no. 620996) as part of the project titled: An optical neuro-monitor of cerebral oxygen metabolism and blood flow for neonatology (BabyLux).

Author information

Substantial contributions to conception, design, data acquisition. or analysis or interpretation: All. Drafting and revising article: B.A., A.D.C., M.F., M.G., D.C., L.S., A.T., G.G. Final approval: All.

Correspondence to Gorm Greisen.

Ethics declarations

Competing interests

The IP generated during the BabyLux project is owned by the technological partners. U.M.W. is the CEO, has equity ownership in HemoPhotonics S.L., and is an employee in the company. His role in the project has been defined by the project objectives, tasks, and work-packages, and was reviewed by the European Commission. The other authors declare no competing interests.

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