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Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children

Pediatric Research (2019) | Download Citation




Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.


A case–control study with 1092 Chinese children was conducted.


We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (Pinteraction = 0.027), and rs12487736 was associated with SBP in the subgroup having high calorie foods at least once in the last week (b = 2.19, P = 0.025), but not in the subgroup not having high calorie foods. Also, interaction between protein intake (meat/fish/soy beans/egg) and rs12487736 on diastolic BP (DBP) was identified (Pinteraction = 0.049); rs12487736 was associated with DBP in the subgroup consuming protein (meat/fish/soy beans/egg) <twice/day (b = 3.38, P = 0.014), but not in the subgroup ≥twice/day. There is combined effect between rs12487736 and physical activity on DBP. In the subgroup who were inactive (physical activity <1 h/day), rs12487736 was significantly associated with DBP (b = 3.27, P = 0.046), but not in the active group (physical activity ≥1 h/day). Similar combined effect between rs12487736 and soft drink was found.


Interactions or combined effects between SCAP and lifestyle behaviors on BP support the importance of promoting a healthy lifestyle in the children genetically predisposed to higher BP.

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This study was supported by Grants from National Natural Science Foundation of China (81573170, H.-J.W., http://www.nsfc.gov.cn/), National Natural Science Foundation of China (81673192, J.M., http://www.nsfc.gov.cn/), Hunan Provincial Natural Science Foundation of China (2019JJ50376, Y.-D.Y.) and a project supported by Scientific Research Fund of Hunan Provincial Education Department (18C0072, Y.-D.Y.).

Author information


  1. Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China

    • Yi-De Yang
    • , Jie-Yun Song
    • , Shuo Wang
    • , Bin Dong
    •  & Jun Ma
  2. Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China

    • Yi-De Yang
  3. Department of Maternal and Child Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China

    • Yang Wang
    • , Qi-ying Song
    • , Chen-Xiong Li
    •  & Hai-Jun Wang


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The authors declare no competing interests.

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Correspondence to Hai-Jun Wang or Jun Ma.

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