Basic Science Article | Published:

Pseudomonas aeruginosa-derived exosomes ameliorates allergic reactions via inducing the Treg response in asthma

Pediatric Researchvolume 84pages125133 (2018) | Download Citation




Exosomes are nanovesicles originating from multivesicular bodies that have complex functions and significant therapeutic effects in many diseases. In the present study, we successfully extracted exosomes from Pseudomonas aeruginosa and assessed the effect of those exosomes on the development of the allergic response in two types of classic asthma models.


Female BALB/c mice were administrated with P. aeruginosa-derived exosomes 1 week before ovalbumin (OVA) or house dust mite (HDM) sensitization. Bronchoalveolar lavage fluid, serums and lung tissues were collected and analyzed for pathophysiology and immune responses.


Our results demonstrated that P. aeruginosa-derived exosomes inhibited the development of airway hyper-responsiveness (AHR), peribronchial and perivascular inflammation in lung tissues and the level of serum IgE. Moreover, this protective effect was associated with an increase in the regulatory T cell (Treg) response and a concomitant decreased Th2 response.


In conclusion, these observations demonstrated that P. aeruginosa-derived exosomes could induce protection against allergic sensitization in asthma mice, and our study provided a new insight to prevent allergic diseases.

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This work was supported by the Program for Innovative Research Team at Chongqing University, 2013.

Author information


  1. Department of Pediatric Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, China

    • Feng-Xia Ding
    • , Wen-Jing Zou
    • , Qu-bei Li
    • , Dai-yin Tian
    •  & Zhou Fu
  2. Ministry of Education Key Laboratory of Child Development and Disorder, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing, 400014, China

    • Feng-Xia Ding
    • , Bo Liu
    • , Wen-Jing Zou
    • , Qu-bei Li
    • , Dai-yin Tian
    •  & Zhou Fu
  3. Department of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, China

    • Bo Liu


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The authors declare no competing interests.

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Correspondence to Zhou Fu.

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