Fig. 6: CRMP2, YES1, and MAPRE1 are direct targets of miR-93. | Oncogenesis

Fig. 6: CRMP2, YES1, and MAPRE1 are direct targets of miR-93.

From: MiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamics

Fig. 6

a Schematic representation of pEZX-MT05 vector. b Predicted interactions between miR-93 and CRMP2, YES1, and MAPRE1 mRNA 3′-UTR region. c CRMP2, YES1, and MAPRE1 luciferase reporter assays (wild-type and mutated) in HEK293T cells transfected with either miR-93 mimic or scramble; luciferase activity normalized against alkaline phosphatase activity; n = 3, error bars = s.d., *p ≤ 0.05. d Schematic representation of miR-93 regulation of the proposed targets in PDAC. In this context, miR-93 demonstrates the ability of targeting multiple protein coding genes from the same signaling pathway (microtubule dynamics), at different levels.

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