Fig. 5: Glutamine synthetase is necessary for sarcoma tumor growth. | Oncogenesis

Fig. 5: Glutamine synthetase is necessary for sarcoma tumor growth.

From: Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth

Fig. 5

a Tumor volumes at day 20 postorthotopic injection of TC71 Ewing sarcoma stable cell lines expressing the indicated shRNAs. Each data point represents the tumor volume of one mouse, and the broken line represents the average tumor volume for the group. Mice were treated with 10 mg/kg MSO or saline, IP, 3 times/week, as indicated. *p < 0.05, **p < 0.005 by Student t test, compared to shControl + Vehicle. b Kaplan–Meier analysis of overall survival of Ewing sarcoma patients with respect to glutamine synthetase expression, demonstrating that higher expression is correlated with worse overall survival. Analysis (Kaplan–Meier by gene expression) of the “Tumor Ewing Sarcoma (Core Transcript) - Dirksen - 85 - rma_sketch - huex10t” dataset (comprised of 85 samples) was performed using R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl)

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