Fig. 6: Transforming activity of Vav1 mutants in vivo. | Oncogenesis

Fig. 6: Transforming activity of Vav1 mutants in vivo.

From: Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes

Fig. 6

a NIH3T3 cells stably expressing pcDNA3, Vav1, oncVav1, E59K, D517E, and L801P were injected subcutaneously into athymic female NOD/SCID mice. The histogram shows the mean tumor sizes of 3 experiments 30 days following injection ( ± SE). Six mice were used for each group in each experiment. Differences between tumors generated by oncVav1, E59K, D517E, and Vav1 are, as indicated, highly significant (*unpaired Student’s t test). b Photographs of representative tumors 30 days post-injection are depicted

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