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Crosstalk between m6A regulators and mRNA during cancer progression

Oncogene volume 41, pages 4407–4419 (2022)Cite this article

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Abstract

m6A modification, the most abundant and widespread RNA modification, is present and involved in the occurrence and development of various cancers. To date, most studies have mainly focused on the roles of a single m6A regulator (writer/eraser/reader) in various cancers, but cumulative evidence shows that aberrant m6A regulators and m6A levels exert dual effects (promoting and/or inhibiting roles) in cancer progression. Recently, studies have investigated the direct interactions between different m6A regulators (writer/eraser and reader) and mRNAs in a variety of cancers. In this review, we summarize the functions of m6A regulators and their roles in various types of cancers. We further propose the possible crosstalk mechanisms (Writer-m6A-Reader-mRNA axis and Eraser-m6A-Reader-mRNA axis) between different m6A regulators and mRNAs during cancer progression. We also discuss the clinical potential of m6A regulator‑targeting strategies.

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Fig. 1: Regulators and roles of RNA m6A modification.
Fig. 2: Aberrant expression of m6A regulators in various human cancers.
Fig. 3: Summary of Writer-m6A-Reader-mRNA axis and Eraser-m6A-Reader-mRNA axis in cancer from the perspective of m6A regulators (underlines).
Fig. 4: Summary of possible crosstalk mechanisms underlying m6A modification in cancer from the perspective of m6A and mRNAs levels.
Fig. 5: Summary of regulative mechanisms underlying m6A modification on oncogenic mRNA MYC in various cancers.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81902532 to YY and 82072773 to QM), the fellowship of China Postdoctoral Science Foundation (2022M712255 to XDN), the National Key Research and Development Program of China, Stem Cell and Translational Research (2017YFA0106500 to YW), the Distinguished Young Scientists Program of Sichuan Province (2019JDJQ0029 to YW), and the 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYYC20019 to YW).

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  1. Department of Neurosurgery and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China

    Xiaodong Niu, Yuan Yang, Yanming Ren, Qing Mao & Yuan Wang

  2. Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China

    Shengtao Zhou

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Manuscript conception and design: XDN, YY, QM, and YW. Literature search and manuscript drafting: XDN and YY. Manuscript editing, figure design, and review: all authors. All authors have read and approved the final manuscript.

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Niu, X., Yang, Y., Ren, Y. et al. Crosstalk between m6A regulators and mRNA during cancer progression. Oncogene 41, 4407–4419 (2022). https://doi.org/10.1038/s41388-022-02441-4

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