Table 2 Association of risk factors with recurrence and survival of breast cancer in univariate and multivariable analysis.

From: Transmembrane and coiled-coil domain family 3 (TMCC3) regulates breast cancer stem cell and AKT activation

Variables RFS OS
Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis
HR 95% CI p value HR 95% CI p value HR 95% CI p value HR 95% CI p value
Age: ≥50 vs <50 2.74 1.43–5.24 0.002 2.54 1.32–4.89 0.005 2.66 1.42–4.96 0.002 2.35 1.25–4.43 0.008
Grade: III vs I + II 1.89 1.04–3.46 0.038     1.89 1.06–3.40 0.032    
Stage: III + IV vs I + II 1.74 0.94–3.23 0.08     2.81 1.62–4.89 0.001 2.38 1.36–4.17 0.002
ER: (+) vs (−) 0.63 0.36–1.08 0.09     1.13 0.65–1.97 0.66    
PR: (+) vs (−) 0.59 0.34–1.03 0.06     0.79 0.45–1.38 0.40    
HER2: (+) vs (−) 0.86 0.49–1.50 0.59     0.88 0.51–1.51 0.64    
TMCC3 Tumor: high vs low 3.32 1.89–5.83 0.001 2.81 1.45–5.45 0.002 2.92 1.69–5.02 0.001 2.28 1.31–3.96 0.004
  1. RFS relapse-free survival, OS overall survival, HR hazard ratio, CI confidence interval.
  2. Bold values indicate statistical significance p < 0.05.