Fig. 3: rIL-17B promoted the tumorigenic ability and growth of subcutaneous tumors of GC cells. | Oncogene

Fig. 3: rIL-17B promoted the tumorigenic ability and growth of subcutaneous tumors of GC cells.

From: IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination

Fig. 3

A Representative images of subcutaneous tumors in nude mice. B Images of subcutaneous xenografts in nude mice. C–E The incidence rate (C), tumor volume (D), and tumor weight (E) were monitored for the indicated tumor (n = 4; *p < 0.05; **p < 0.01; and ***p < 0.001). F HE and immunohistochemical staining showed the expression of ki67, cyclin-D1, Sox9, Sox2, and CK18 in subcutaneous tumor tissues. G HGC-27-shIL-17RB cells treated with 200 ng/ml rIL-17B and HGC-27-shControl cells treated with 200 ng/ml rIL-17Bor PBS for 48 h, these cells were diluted and subcutaneously injected into nude mice. Tumors were examined over a 8 days period (n = 8 for each group).

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