Fig. 7: Proposed model for the role of SFPQ/p54nrb in PT response in EOC. | Oncogene

Fig. 7: Proposed model for the role of SFPQ/p54nrb in PT response in EOC.

From: Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity

Fig. 7

SFPQ, in complex with p54nrb, binds and regulates the activity of the splicing factor SRSF2, already identified as a key factor in caspase-9 alternative splicing regulation. In basal conditions, SFPQ/p54nrb complex prevents/decreases SRSF2 binding to caspase-9 RNA, favoring the expression of its antiapoptotic alternative spliced form and promoting cell survival. SFPQ/p54nrb downregulation augment the binding of SRSF2 to caspase-9 RNA and leads to increased expression of caspase-9 proapoptotic isoform, inducing cell death, in particular under platinum treatment. In this manner SFPQ/p54nrb complex protect EOC cells from PT-induced death, eventually contributing to chemoresistance.

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