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Alterations of T-cell-mediated immunity in acute myeloid leukemia

Oncogene volume 39, pages 3611–3619 (2020)Cite this article

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Abstract

Acute myeloid leukemia (AML) is a systemic, heterogeneous hematologic malignancy with poor overall survival. While some malignancies have seen improvements in clinical outcomes with immunotherapy, success of these agents in AML remains elusive. Despite limited progress, stem cell transplantation and donor lymphocyte infusions show that modulation of the immune system can improve overall survival of AML patients. Understanding the causes of immune evasion and disease progression will identify potential immune-mediated targets in AML. This review explores immunosuppressive mechanisms that alter T-cell-mediated immunity in AML.

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Fig. 1: Proposed mechanisms of T-cell suppression and promotion of T-cell dysfunction by AML.

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Acknowledgements

The authors are supported by K23HL138291(PBF) and T32CA217834 (ZL).

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA

    Zhuoyan Li, Mary Philip & P. Brent Ferrell

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  1. Zhuoyan Li
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  2. Mary Philip
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  3. P. Brent Ferrell
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Correspondence to P. Brent Ferrell.

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Conflict of interest

PBF receives research funding support from Incyte, Forma Therapeutics, and Astex Pharmaceuticals and has consulted for Agios Pharmaceuticals. ZL and MP have no competing interests to declare.

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Li, Z., Philip, M. & Ferrell, P.B. Alterations of T-cell-mediated immunity in acute myeloid leukemia. Oncogene 39, 3611–3619 (2020). https://doi.org/10.1038/s41388-020-1239-y

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