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Vesiclemia: counting on extracellular vesicles for glioblastoma patients


Although rare, glioblastoma is a devastating tumor of the central nervous system characterized by a poor survival and an extremely dark prognosis, making its diagnosis, treatment, and monitoring highly challenging. Numerous studies have highlighted extracellular vesicles (EVs) as key players of tumor growth, invasiveness, and resistance, as they carry oncogenic material. Moreover, EVs have been shown to communicate locally in a paracrine way but also at remote throughout the organism. Indeed, recent reports demonstrated the presence of brain tumor-derived EVs into body fluids such as plasma and cerebrospinal fluid. Fluid-associated EVs have indeed been suspected to reflect quantitative and qualitative information about the status and fate of the tumor and can potentially act as a resource for noninvasive biomarkers that might assist in diagnosis, treatment, and follow-up of glioblastoma patients. Here, we coined the name vesiclemia to define the concentration of plasmatic EVs, an intuitive term to be directly transposed in the clinical jargon.

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Fig. 1: Biogenesis, nomenclature, and specific markers of extracellular vesicles.
Fig. 2: Separation and characterization of extracellular vesicles.
Fig. 3: Possible functions of extracellular vesicles within the glioblastoma microenvironment.
Fig. 4: Use of plasmatic extracellular vesicles in clinics.


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We thank SOAP team members (Nantes, France). The research from the team was funded by Fondation pour la Recherche Medicale (Equipe labellisée DEQ20180339184), Fondation ARC contre le Cancer (PJA20171206146, PJA20191209477, PGA1 RF20190208474), INCa PLBIO (2019-151, 2019-291), Ligue nationale contre le cancer comités de Loire-Atlantique, Maine et Loire, Vendée, Ille-et-Vilaine, SIRIC ILIAD (INCa-DGOS-Inserm_12558) and Région Pays de la Loire et Nantes Métropole under Connect Talent Grant. QS received Master internship fellowship from ITMO Cancer (Plan Cancer 2014−2019).

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Correspondence to Julie Gavard.

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Sabbagh, Q., Andre-Gregoire, G., Guevel, L. et al. Vesiclemia: counting on extracellular vesicles for glioblastoma patients. Oncogene 39, 6043–6052 (2020).

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