Fig. 8 | Oncogene

Fig. 8

From: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Fig. 8

Exo-circ-DB and USP7 regulates Deubiquitination of cyclin A2. HCC cells were treated as described above, and immune-precipitation was used to analyze the level of ubiquitination. a WB analysis of Cyclin A2 ubiquitination in HCC cells treated with 3T3 exosomes (n = 3). b WB analysis of Cyclin A2 ubiquitination in HCC cells treated with USP7 plasmid or USP7 siRNA (n = 3). c WB analysis of Cyclin A2 ubiquitination in HCC cells treated with circ-DB plasmid or circ-DB siRNA (n = 3). d WB analysis of Cyclin A2 ubiquitination in HCC cells treated with miR-34a mimics or miR-34a inhibitors (n = 3). **p < 0.01

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