Fig. 7 | Oncogene

Fig. 7

From: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Fig. 7

Role of circ-DB and USP7 in regulating proliferation and DNA damage in HCC cells. HCC cells were pretreated with circ-DB overexpressing plasmid (OE.circ-DB) and circ-DB siRNA deleted by circ-DB siRNA (si.circ-DB). a, b The cells were stained with DAPI and EdU, and then, the nuclei were imaged to reveal the proliferation of HCC cells (n = 3). c, d The cells were stained with DAPI and H2AFX, and then, the nuclei were imaged (n = 3). HCC cells were pretreated with USP7-overexpressing plasmid (OE.USP7) and USP7 siRNA (si.USP7). e, f The cells were stained with DAPI and EdU, and then, the nuclei were imaged to reveal the proliferation of HCC cells (n = 3). g, h The cells were stained with DAPI and H2AFX, and then, the nuclei were imaged (n = 3). **p < 0.01

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