Fig. 4 | Oncogene

Fig. 4

From: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Fig. 4

The expression of miR-34a, USP7, and Cyclin A2 is regulated by adipocyte exosomes. a Transmission electron microscopy image of 3T3L1 exosomes (scale bar, 100 nm). b CD63, Alix, and Tsg101 expression as detected by WB. c Oil red O staining of mature adipocytes and pre-adipocytes. d, e The difference in circ-DB expression in mature and pre-adipocytes (d), as well as in exosomes from 3T3L1 cells (e) (n = 3). f Graphical representation of HCC cells treated with mature adipocyte exosomes. gi Quantification of miR-34a and the expression levels of USP7 and cyclin A2 in HCC cells treated with mature adipocyte exosomes (n = 3). **p < 0.01

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