Fig. 2 | Oncogene

Fig. 2

From: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Fig. 2

Clinical relevance among exo-circ-DB, miR-34a and USP7 in HCC. a The expression of USP7 in para-carcinoma tissues (P) and tumor tissues (T) was detected by immunohistochemistry (IHC). Scale bar, 100 μm. b The HCC patients were divided into two groups according to the mean value of USP7 mRNA. The expression of USP7 was closely linked with the survival in HCC (n = 1595 in high group, and n = 2356 in low group). ce The levels of exo-circ-DB, miR34a of tumors and USP7 of tumors in the above-the-median group and below-the-median group (n = 21 and n = 19, respectively). f, g The negative relationship between exo-circ-DB and miR-34a (n = 21, R = 0.735), as well as between miR-34a and USP7 (n = 21, R = 0.762). **p < 0.01

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