Fig. 1 | Oncogene

Fig. 1

From: Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

Fig. 1

The correlation between exo-circ-DB and USP7 in HCC. a TEM image of exosomes isolated from human plasma (scale bar, 100 nm). b Plasma exosomes were isolated from both normal subjects (NC) and HCC patients. Western blotting of three representative exosome-specific markers: CD63, Alix, and Tsg101. c The size range of the plasma exosomes checked by NAT analysis. d HCC patients were divided into the above-the-median group (n = 21) and below-the-median group (n = 19) according to the median body fat ratio of the HCC patients. e Preliminary circ-RNA screening of HCC by an Agilent Microarray Scanner (n = 21 and n = 19, respectively). f, g WB analysis of USP7 in the above-the-median group and below-the-median group (n = 21 and n = 19, respectively). h Representative images of the potential interaction between circ-DB and USP7. I. The predicting binding region of miR-34a in USP7 mRNA. J. The clinical relevance between plasma exo-circ-DB and USP7 protein (n = 21). **p < 0.01

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