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Calcitonin receptor signal: a potential target for opioid use disorder?

Neuropsychopharmacology volume 48, pages 1835–1836 (2023)Cite this article

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If we were to ask any addiction neuroscience researcher about their main scientific goal and dream, the overwhelming response would undoubtedly be to discover treatments and targets that can prevent and disrupt the various phases of drug addiction. Throughout the history of our field, this has been the shared objective for our community, spanning several decades [1]. Despite the noble intentions, fervent efforts, and significant investments, the stark reality remains that treatment options have remained largely unchanged [2]. This stagnation in the state of the art has increasingly caused disappointment and raised doubts about the validity of our field. While this background may sound cynical and pessimistic, it is important to note that this is not the end. As scientists in the addiction neuroscience field, we acknowledge our past mistakes and failures. Nevertheless, we persist in our pursuit of creating and proposing new solutions and approaches. We are committed to learning from our previous missteps and are dedicated to the ongoing exploration of innovative avenues [3].

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References

  1. Dole VP, Nyswander M. A medical treatment for diacetylmorphine (heroin) addiction. A clinical trial with methadone hydrochloride. JAMA. 1965;193:646–50.

    Article  CAS  PubMed  Google Scholar 

  2. Epstein DH, Heilig M, Shaham Y. Science-based actions can help address the opioid crisis. Trends Pharmacol Sci. 2018;39:911–16.

    Article  CAS  PubMed  Google Scholar 

  3. Venniro M, Banks ML, Heilig M, Epstein DH, Shaham Y. Improving translation of animal models of addiction and relapse by reverse translation. Nat Rev Neurosci. 2020;21:625–43.

    Article  CAS  PubMed  Google Scholar 

  4. Farokhnia M, Faulkner ML, Piacentino D, Lee MR, Leggio L. Ghrelin: from a gut hormone to a potential therapeutic target for alcohol use disorder. Physiology & behavior. 2019;204:49–57.

    Article  CAS  Google Scholar 

  5. Zhang Y, Nathan JB, Moreno A, Merkel R, Kahng MW, Hayes MR, et al. Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats. Neuropsychopharmacology. 2023. https://doi.org/10.1038/s41386-023-01634-z. Online ahead of print.

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Acknowledgements

We thank Dr. Yavin Shaham for comments and edits on the early version of the paper.

Funding

The research was supported by a grant from NIDA [DA047976] (MV).

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Authors and Affiliations

  1. Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA

    Rosa A. M. Marino & Marco Venniro

  2. Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA

    Marco Venniro

  3. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA

    Marco Venniro

Authors
  1. Rosa A. M. Marino
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  2. Marco Venniro
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RAMM and MV equally contributed to this manuscript.

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Correspondence to Marco Venniro.

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The authors declare no competing interests.

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Marino, R.A.M., Venniro, M. Calcitonin receptor signal: a potential target for opioid use disorder?. Neuropsychopharmacol. 48, 1835–1836 (2023). https://doi.org/10.1038/s41386-023-01702-4

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  • DOI: https://doi.org/10.1038/s41386-023-01702-4

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