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Microbes and mental health: translating preclinical findings to the clinic

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Fig. 1: Original findings from germ-free mice led to the modern-day consideration of the impact of the microbiome on mental health outcomes in humans.


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The authors would like to thank Jane A. Foster for her contributions to the research highlighted above and for her assistance with the creation of this document.


The following funding information is for the manuscript from the authors highlighted above ([6]). The Dallas 2K (D2K) study was funded by the Hersh Foundation and the Rose Foundation. The Resilience in Adolescent Development (RAD) study was funded in part by the W.W. Caruth Jr. Foundation, the Elizabeth Jordan Harris Foundation, the Rose Foundation, and the Hersh Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the various funding organizations. In addition, this work was funded in part by the Center for Depression Research and Clinical Care (PI: Madhukar H. Trivedi) and by the Ontario Brain Institute (PI: Sidney Kennedy).

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CRCF and MHT drafted, edited, and approved the manuscript.

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Correspondence to Madhukar H. Trivedi.

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CRCF has no conflicts to disclose. MHT has served as a consultant or advisor for Acadia Pharmaceuticals, Inc., Akili Interactive, Alkermes, Inc. (Pub Steering Comm-ALKS5461), Allergan Sales LLC, Alto Neuroscience, Inc., Applied Clinical Intelligence, LLC (ACI), Axome Therapeutics, Boehringer Ingelheim, Engage Health Media, Gh Research, GreenLight VitalSign6, Inc., Heading Health, Inc., Health Care Global Village, Janssen – Cilag.SA, Janssen Research and Development, LLC (Adv Committee Esketamine), Janssen Research and Development, LLC (panel for study design for MDD relapse), Janssen – ORBIT, Legion Health, Jazz Pharmaceuticals, Lundbeck Research U.S.A, Medscape, LLC, Merck Sharp & Dohme Corp., Mind Medicine (MindMed) Inc., Myriad Neuroscience, Neurocrine Biosciences Inc, Navitor, Pharmaceuticals, Inc., Noema Pharma AG, Orexo US Inc., Otsuka Pharmaceutical Development & Commercialization, Inc. (PsychU, MDD Section Advisor), Otsuka America Pharmaceutical, Inc. (MDD expert), Pax Neuroscience, Perception Neuroscience Holdings, Inc., Pharmerit International, LP, Policy Analysis Inc., Rexahn Pharmaceuticals, Inc., Sage Therapeutics, Signant Health, SK Life Science, Inc., Takeda Development Center Americas, Inc., The Baldwin Group, Inc., and Titan Pharmaceuticals, Inc. MHT also received editorial compensation from Oxford University Press.

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Chin Fatt, C.R., Trivedi, M.H. Microbes and mental health: translating preclinical findings to the clinic. Neuropsychopharmacol. (2023).

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