Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Moving beyond descriptive nosology: an argument for negative valence systems disorder


This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  1. Morris SE, Sanislow CA, Pacheco J, Vaidyanathan U, Gordon JA, Cuthbert BN. Revisiting the seven pillars of RDoC. BMC Med. 2022;20:220.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Forstner BR, Tschorn M, Reinoso-Schiller N, Maricic LM, Rocher E, Kalman JL, et al. Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis. Eur Arch Psychiatry Clin Neurosci. 2023;273:527–39.

    Article  PubMed  Google Scholar 

  3. Paulus MP, Stein MB, Craske MG, Bookheimer S, Taylor CT, Simmons AN, et al. Latent variable analysis of positive and negative valence processing focused on symptom and behavioral units of analysis in mood and anxiety disorders. J Affect Disord. 2017;216:17–29.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Medeiros GC, Rush AJ, Jha M, Carmody T, Furman JL, Czysz AH, et al. Positive and negative valence systems in major depression have distinct clinical features, response to antidepressants, and relationships with immunomarkers. Depress Anxiety. 2020;37:771–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sambuco N, Bradley M, Herring D, Hillbrandt K, Lang PJ. Transdiagnostic trauma severity in anxiety and mood disorders: Functional brain activity during emotional scene processing. Psychophysiology. 2020;57:e13349.

    Article  PubMed  Google Scholar 

  6. Li H, Namburi P, Olson JM, Borio M, Lemieux ME, Beyeler A, et al. Neurotensin orchestrates valence assignment in the amygdala. Nature. 2022;608:586–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations



EKL and REM wrote, edited, and approved the manuscript.

Corresponding author

Correspondence to Robert E. McCullumsmith.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lucas, E.K., McCullumsmith, R.E. Moving beyond descriptive nosology: an argument for negative valence systems disorder. Neuropsychopharmacol. (2023).

Download citation

  • Published:

  • DOI:


Quick links