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Control of dopamine communication by opioids: glutamate enters the discussion

Neuropsychopharmacology volume 48, pages 1833–1834 (2023)Cite this article

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Opioid use disorder (OUD) has become an increasingly widespread public health concern within the United States, affecting nearly 2.7 million individuals over the age of 12 [1]. This, coupled with a rise in opioid-related overdose deaths, has reinvigorated efforts to understand the intricacies of opioid interaction with the brain’s reward circuitry. While heroin, morphine, and related opioids have long been known to act through mu opioid receptors (MORs) to mediate the rewarding effects of these drugs, defining the cellular substrates at which MORs influence reward-seeking behavior remains an ongoing process.

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References

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Funding

CRL and AFH are supported by the Intramural Research Program of NIH, NIDA.

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Authors and Affiliations

  1. U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Computational and Systems Neuroscience Branch, Electrophysiology Research Section, Baltimore, MD, 21224, USA

    Carl R. Lupica & Alexander F. Hoffman

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  1. Carl R. Lupica
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  2. Alexander F. Hoffman
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AFH wrote the initial draft. CRL reviewed, edited, and prepared the final submission. Both authors reviewed, edited, and approved the final version.

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Correspondence to Alexander F. Hoffman.

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The authors declare no competing interests.

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Lupica, C.R., Hoffman, A.F. Control of dopamine communication by opioids: glutamate enters the discussion. Neuropsychopharmacol. 48, 1833–1834 (2023). https://doi.org/10.1038/s41386-023-01683-4

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