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Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient

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Funding

Funding

This work was supported by NIH/NIMH R01MH107615 and U.S. Department of Veterans Affairs Merit Awards 1I01BX004062 and 1I01BX006018 to TDG. The binding and functional profile of BZT were performed by the National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP; University of North Carolina, Chapel Hill, NC; Contract # HHSN-271-2018-00023-C). The NIMH PDSP is directed by Bryan L. Roth at the University of North Carolina at Chapel Hill and Project Officer Jamie Driscoll at NIMH, Bethesda MD, USA. The contents of this manuscript do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.

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KAB and TDG contributed to the conception of the work; KAB wrote the manuscript and TDG critically revised the work.

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Correspondence to Todd D. Gould.

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Competing interests

TDG has received research funding from Allergan Pharmaceuticals during the preceding three years. TDG is listed as an inventor in patents and patent applications related to the pharmacology and use of a ketamine metabolite, (2R,6R)-hydroxynorketamine, in the treatment of depression, anxiety, anhedonia, suicidal ideation, and post-traumatic stress disorders. TDG has assigned his patent rights to the University of Maryland, Baltimore, but will share a percentage of any royalties that may be received by the University of Maryland, Baltimore. KAB declares no competing interests.

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Brown, K.A., Gould, T.D. Disassociating drug active ingredients from inactive: ketamine-like synaptic effects of a ketamine excipient. Neuropsychopharmacol. 49, 301–302 (2024). https://doi.org/10.1038/s41386-023-01675-4

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