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For neuroscience, social history matters

Neuropsychopharmacology (2023)Cite this article

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References

  1. Dwortz MF. et al. Neural systems that facilitate the representation of social rank. Philos Trans R Soc Lond B Biol Sci. 2022;377:20200444.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Williamson CM. et al. Social context-dependent relationships between mouse dominance rank and plasma hormone levels. Physiol Behav. 2017;171:110–9.

    Article  CAS  PubMed  Google Scholar 

  3. Opendak M, Gould E, Sullivan R. Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior. Dev Cogn Neurosci. 2017;25:145–59.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Fulenwider HD, Caruso MA, Ryabinin AE. Manifestations of domination: Assessments of social dominance in rodents. Genes Brain Behav. 2022;21:e12731.

    Article  PubMed  Google Scholar 

  5. Jones CE, Monfils M-H. Dominance status predicts social fear transmission in laboratory rats. Anim Cogn. 2016;19:1051–69.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Padilla-Coreano N, Tye KM, Zelikowsky M. Dynamic influences on the neural encoding of social valence. Nat Rev Neurosci. 2022;23:535–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Zhou T. et al. History of winning remodels thalamo-PFC circuit to reinforce social dominance. Science. 2017;357:162–8.

    Article  CAS  PubMed  Google Scholar 

  8. Basil AH. et al. Social defeat-induced Cingulate gyrus immediate-early gene expression and anxiolytic-like effect depend upon social rank. Brain Res Bull. 2018;143:97–105.

    Article  CAS  PubMed  Google Scholar 

  9. Forkosh O. et al. Identity domains capture individual differences from across the behavioral repertoire. Nat Neurosci. 2019;22:2023–8.

    Article  CAS  PubMed  Google Scholar 

  10. Grieco F. et al. Measuring behavior in the home cage: study design, applications, challenges, and perspectives. Front Behav Neurosci. 2021;15:735387.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Drickamer LC. Urine marking and social dominance in male house mice (Mus musculus domesticus). Behav Process. 2001;53:113–20.

    Article  Google Scholar 

  12. Wang F. et al. Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science. 2011;334:693–7.

    Article  CAS  PubMed  Google Scholar 

  13. Militzer K, Reinhard HJ. Rank positions in rats and their relations to tissue parameters. Physiol Psychol. 1982;10:251–60.

    Article  Google Scholar 

  14. Lee CR, Chen A, Tye KM. The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. Cell. 2021;184:1500–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Tomova L. et al. Acute social isolation evokes midbrain craving responses similar to hunger. Nat Neurosci. 2020;23:1597–605.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Matthews GillianA. et al. Dorsal raphe dopamine neurons represent the experience of social isolation. Cell. 2016;164:617–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Weiss IC. et al. Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat. Behav Brain Res. 2004;152:279–95.

    Article  CAS  PubMed  Google Scholar 

  18. Ma X-c. et al. Social isolation-induced aggression potentiates anxiety and depressive-like behavior in male mice subjected to unpredictable chronic mild stress. PLoS One. 2011;6:e20955.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Matsumoto K. et al. Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress. 2005;8:85–93.

    Article  CAS  PubMed  Google Scholar 

  20. Zelikowsky M. et al. The neuropeptide Tac2 controls a distributed brain state induced by chronic social isolation stress. Cell. 2018;173:1265–1279.e19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Kessler RC. et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2018;197:378–85.

    Article  Google Scholar 

  22. Waters RC, Gould E. Early life adversity and neuropsychiatric disease: differential outcomes and translational relevance of rodent models. Front Syst Neurosci. 2022;16:860847.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Walker C-D. et al. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress. 2017;20:421–48.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Sullivan RM, Opendak M. Neurobiology of infant fear and anxiety: impacts of delayed amygdala development and attachment figure quality. Biol Psychiatry. 2021;89:641–50.

    Article  PubMed  Google Scholar 

  25. Butler-Struben HM, Kentner AC, Trainor BC. What’s wrong with my experiment?: The impact of hidden variables on neuropsychopharmacology research. Neuropsychopharmacology. 2022;47:1285–1291.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Kennedy Krieger Institute, Baltimore, MD, 21205, USA

    Anne George & Maya Opendak

  2. Evelyn F. & William McKnight Brain Institute and Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA

    Nancy Padilla-Coreano

  3. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Maya Opendak

Authors
  1. Anne George
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  2. Nancy Padilla-Coreano
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  3. Maya Opendak
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Contributions

AG, NPC, and MO wrote the manuscript.

Corresponding author

Correspondence to Maya Opendak.

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The authors declare no competing interests.

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George, A., Padilla-Coreano, N. & Opendak, M. For neuroscience, social history matters. Neuropsychopharmacol. (2023). https://doi.org/10.1038/s41386-023-01566-8

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  • DOI: https://doi.org/10.1038/s41386-023-01566-8

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