Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Kappa opioid receptors as modulators of novelty processing


A Correction to this article was published on 03 May 2023

This article has been updated

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Change history


  1. Wee S, Koob GF. The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology. 2010;210:121–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Bruchas MR, Land BB, Chavkin C. The Dynorphin-Kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res. 2010;1314C:44.

    Article  Google Scholar 

  3. Pirino BE, Spodnick MB, Gargiulo AT, Curtis GR, Barson JR, Karkhanis AN. Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis. Neuropharmacology. 2020;181:108341.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Farahbakhsh ZZ, Song K, Branthwaite HE, Erickson KR, Mukerjee S, Nolan SO, et al. Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice. Neuropsychopharmacology. 2023:1–12.

  5. Lewis AS, Calipari ES, Siciliano CA. Toward standardized guidelines for investigating neural circuit control of behavior in animal research. ENeuro. 2021;8:1–6.

Download references


This work was funded by grant R00DA049862, the McDonnell Center for Cellular and Molecular Neurobiology, and the McDonnell Center for Systems Neuroscience.

Author information

Authors and Affiliations



KB: Draft preparation and review; DCC: reviewing, editing, and preparation of final submission.

Corresponding author

Correspondence to Daniel C. Castro.

Ethics declarations

Competing interests

The authors declare that they have no competing interests or disclosures with this publication.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The original online version of this article was revised due to a retrospective Open Access cancellation.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Braden, K., Castro, D.C. Kappa opioid receptors as modulators of novelty processing. Neuropsychopharmacol. 48, 848–849 (2023).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


Quick links