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Compulsion and substance use disorder: potential importance of boundary conditions

Neuropsychopharmacology volume 48, pages 432–433 (2023)Cite this article

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For the past several decades, preclinical modeling of substance use disorders (SUDs) has shifted away from tolerance and withdrawal, toward the creation of models thought to reflect translationally relevant aspects of the clinical condition. A telescoped focus has been placed on creating non-human models in attempt to recapitulate the behavioral aspects of human SUD, including escalation of drug use, taking drug despite negative consequences, drug seeking when the drug is unavailable or the response is associated with adverse consequences as a model of “compulsivity”, among others [1]. These models have resulted in a plethora of information regarding the neurobiology of various animal subgroups, defined by observed behavior within specific experimental contexts.

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References

  1. Deroche-Gamonet V, Belin D, Piazza PV. Evidence for addiction-like behavior in the rat. Science. 2004;305:1014–7.

    Article  CAS  Google Scholar 

  2. Pascoli V, Hiver A, Li Y, Harada M, Esmaeili V, Lüscher C. Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice. Neuropsychopharmacology. 2022. https://doi.org/10.1038/s41386-022-01429-8.

  3. Nebe S, Kroemer NB, Schad DJ, Bernhardt N, Sebold M, Muller DK, et al. No association of goal-directed and habitual control with alcohol consumption in young adults. Addict Biol. 2018;23:379–93.

    Article  Google Scholar 

  4. Hogarth L. Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory. Neuropsychopharmacology. 2020;45:720–35.

    Article  Google Scholar 

  5. Heyman GM. How individuals make choices explains addiction’s distinctive, non-eliminable features. Behav Brain Res. 2021;15:397.

    Google Scholar 

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Funding

Authors are supported by DA046526 and DA049130 (to CGR), and DA045023 and DA047368 (to JSB).

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Authors and Affiliations

  1. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA

    Cassandra D. Gipson

  2. Department of Psychology, University of Kentucky, Lexington, KY, USA

    Joshua S. Beckmann

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  1. Cassandra D. Gipson
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  2. Joshua S. Beckmann
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CDG wrote the initial draft of the commentary, and JSB contributed additional text. Both CDG and JSB edited the manuscript and approved the final version.

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Correspondence to Cassandra D. Gipson.

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The authors declare no competing interests.

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Gipson, C.D., Beckmann, J.S. Compulsion and substance use disorder: potential importance of boundary conditions. Neuropsychopharmacol. 48, 432–433 (2023). https://doi.org/10.1038/s41386-022-01462-7

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  • DOI: https://doi.org/10.1038/s41386-022-01462-7

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