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Using metabolic imaging to investigate neuromodulatory mechanisms of rTMS

Neuropsychopharmacology volume 48, pages 209–210 (2023)Cite this article

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Repetitive transcranial magnetic stimulation (rTMS) induces varieties of behavioral effects ranging from cognitive domains to FDA-approved treatments for migraine and depression. Despite these exciting applications, open questions remain about rTMS mechanisms. Through studies that combine TMS with other measures (neuroimaging, electroencephalogram, etc.), we have gained a better understanding of how rTMS influences brain activity; however, these findings leave gaps in our knowledge of the neurochemical underpinnings of how rTMS affects behavior. Neurochemical and related metabolic fluctuations covary with cognitive and disease states and may inform variations in treatment outcome. Investigating the influence of rTMS on metabolism provides the potential to use metabolite concentrations as predictors of TMS response given that rTMS is designed to change behavior via neural effects.

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References

  1. Cuypers K, Marsman A. Transcranial magnetic stimulation and magnetic resonance spectroscopy: Opportunities for a bimodal approach in human neuroscience. NeuroImage. 2021;224:117394.

    Article  CAS  PubMed  Google Scholar 

  2. Croarkin PE, Nakonezny PA, Wall CA, Murphy LL, Sampson SM, Frye MA, et al. Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents. Psychiatry Res Neuroimaging. 2016;247:25–33.

    Article  PubMed  Google Scholar 

  3. Bagga P, Pickup S, Crescenzi R, Martinez D, Borthakur A, D'Aquilla K, et al. In vivo GluCEST MRI: Reproducibility, background contribution and source of glutamate changes in the MPTP model of Parkinson’s disease. Sci Rep. 2018;8:2883.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, et al. Magnetic resonance imaging of glutamate. Nat Med. 2012;18:302–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cember A, Deck BL, Kelkar A, Faseyitan O, Zimmerman JP, Erickson B. et al. Glutamate-Weighted Magnetic Resonance Imaging (GluCEST) detects effects of transcranial magnetic stimulation to the motor cortex. NeuroImage. 2022;256:119191. https://doi.org/10.1016/j.neuroimage.2022.119191.

    Article  PubMed  Google Scholar 

Download references

Funding

The work was funded by RF1MH116920 and R01MH120811 to DJO.

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Authors and Affiliations

  1. Center for Neuromodulation in Depression and Stress (CNDS), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Joseph A. Deluisi & Desmond J. Oathes

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  1. Joseph A. Deluisi
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  2. Desmond J. Oathes
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JAD and DJO wrote the paper.

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Correspondence to Joseph A. Deluisi.

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The authors declare no competing interests.

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Deluisi, J.A., Oathes, D.J. Using metabolic imaging to investigate neuromodulatory mechanisms of rTMS. Neuropsychopharmacol. 48, 209–210 (2023). https://doi.org/10.1038/s41386-022-01432-z

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  • DOI: https://doi.org/10.1038/s41386-022-01432-z

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