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Sleep disturbance in substance use disorders: the orexin (hypocretin) system as an emerging pharmacological target

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  1. Guo R, Vaughan DT, Almeida Rojo AL, Huang YH. Sleep-mediated regulation of reward circuits: implications in substance use disorders. Neuropsychopharmacology. 2022.

  2. James MH, Fragale JE, Aurora RN, Cooperman NA, Langleben DD, Aston-Jones G. Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: why sleep on this any longer?. Neuropsychopharmacology. 2020;45:717–9.

    Article  Google Scholar 

  3. Mehr JB, Bilotti MM, James MH. Orexin (hypocretin) and addiction. Trends Neurosci. 2021;44:852–5.

    CAS  Article  Google Scholar 

  4. Coleman PJ, Gotter AL, Herring WJ, Winrow CJ, Renger JJ. The discovery of suvorexant, the first orexin receptor drug for insomnia. Annu Rev Pharm Toxicol. 2017;57:509–33.

    CAS  Article  Google Scholar 

  5. Huhn AS, Finan PH, Gamaldo CE, Hammond AS, Umbricht A, Bergeria CL. et al. Suvorexant ameliorated sleep disturbance, opioid withdrawal, and craving during a buprenorphine taper. Sci Transl Med. 2022;14:eabn8238

    CAS  Article  Google Scholar 

  6. James MH, Stopper CM, Zimmer BA, Koll NE, Bowrey HE, Aston-Jones G. Increased number and activity of a lateral subpopulation of hypothalamic orexin/hypocretin neurons underlies the expression of an addicted state in rats. Biol Psychiatry. 2019;85:925–35.

    CAS  Article  Google Scholar 

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This work was supported by grants from the National Institute on Drug Abuse (R00 045765) and the Busch Biomedical Grant from the Office for Research at Rutgers University.

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Both UG and MHJ drafted and edited the manuscript.

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Correspondence to Morgan H. James.

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Gyawali, U., James, M.H. Sleep disturbance in substance use disorders: the orexin (hypocretin) system as an emerging pharmacological target. Neuropsychopharmacol. (2022).

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