Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Unexpected circuit-level tradeoffs in human stress resilience

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Relationship of neural circuits to the timeline of resilience.

References

  1. Roeckner AR, Oliver KI, Lebois LAM, van Rooij SJH, Stevens JS. Neural contributors to trauma resilience: A review of longitudinal neuroimaging studies. Transl Psychiatry. 2021;11:508 https://doi.org/10.1038/s41398-021-01633-y

    Article  PubMed  PubMed Central  Google Scholar 

  2. Ke J, et al. A longitudinal fMRI investigation in acute post-traumatic stress disorder (PTSD). Acta Radiol. 2016;57:1387–95.

    Article  Google Scholar 

  3. Lebois LAM, et al. Persistent dissociation and its neural correlates in predicting outcomes after trauma exposure. Am J Psychiatry. https://doi.org/10.1176/appi.ajp.21090911.

  4. Stevens JS, et al. Brain-based biotypes of psychiatric vulnerability in the acute aftermath of trauma. Am J Psychiatry. 2021;178:1037–49. https://doi.org/10.1176/appi.ajp.2021.20101526

    Article  PubMed  Google Scholar 

  5. Miller GE, White SF, Chen E, Nusslock R. Association of inflammatory activity with larger neural responses to threat and reward among children living in poverty. Am J Psychiatry. 2021;178:313–20.

    Article  Google Scholar 

  6. Williams LM. Precision psychiatry: a neural circuit taxonomy for depression and anxiety. Lancet Psychiatry. 2016;3:472–80. https://doi.org/10.1016/S2215-0366(15)00579-9

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This work was supported by F32 MH126623 to ARR.

Author information

Authors and Affiliations

Authors

Contributions

JSS and ARR identified the topic area, wrote and edited the article, and JSS created the figure.

Corresponding author

Correspondence to Jennifer S. Stevens.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Stevens, J.S., Roeckner, A.R. Unexpected circuit-level tradeoffs in human stress resilience. Neuropsychopharmacol. (2022). https://doi.org/10.1038/s41386-022-01399-x

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41386-022-01399-x

Search

Quick links