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Unexpected circuit-level tradeoffs in human stress resilience

Neuropsychopharmacology (2022)Cite this article

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Much of the psychiatric literature indicates that stress resilience requires effective regulation of negative emotion, and continued capacity for positive emotion. This model heavily influences our understanding of affective disorders. However, emerging evidence suggests that the picture is more complex, and that boosting emotion regulation circuits may even be harmful in some cases. Neural circuits supporting stress resilience change over the course of recovery, and certain features are adaptive in some individuals but not in others. We conceptualize these differences in terms of brain circuit-level tradeoffs.

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Fig. 1: Relationship of neural circuits to the timeline of resilience.

References

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Funding

This work was supported by F32 MH126623 to ARR.

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Authors and Affiliations

  1. Emory University School of Medicine, Atlanta, GA, USA

    Jennifer S. Stevens & Alyssa R. Roeckner

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  1. Jennifer S. Stevens
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  2. Alyssa R. Roeckner
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JSS and ARR identified the topic area, wrote and edited the article, and JSS created the figure.

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Correspondence to Jennifer S. Stevens.

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The authors declare no competing interests.

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Stevens, J.S., Roeckner, A.R. Unexpected circuit-level tradeoffs in human stress resilience. Neuropsychopharmacol. (2022). https://doi.org/10.1038/s41386-022-01399-x

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  • DOI: https://doi.org/10.1038/s41386-022-01399-x

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