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Echoes of ancient DNA in living modern humans affect risk for neuropsychiatric disease and brain structure and function of networks subserving higher-order cognition

Neuropsychopharmacology volume 48, pages 236–237 (2023)Cite this article

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New, ground-breaking technological advances have enabled sequencing of ancient DNA from fossil remains, revealing unprecedented insights into our evolutionary biology and genetic influences on neuropsychiatric disease. These methods have demonstrated that ancestors of modern humans mixed with Neanderthals, our closest evolutionary cousins, approximately 40,000–75,000 years ago [1, 2], leaving residual echoes in our DNA. This inheritance is not just an idle feature of our genome, but is indeed functional in modern humans, for example, imparting changes in keratin to help skin and hair adapt to non-African climates and associating with risk for autoimmune conditions [2].

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References

  1. Prufer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, et al. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature. 2014;505:43–9.

    Article  PubMed  Google Scholar 

  2. Sankararaman S, Mallick S, Dannemann M, Prufer K, Kelso J, Paabo S, et al. The genomic landscape of Neanderthal ancestry in present-day humans. Nature. 2014;507:354–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, et al. Neanderthal-derived genetic variation shapes modern human cranium and brain. Sci Rep. 2017;7:6308.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Gregory MD, Kippenhan JS, Kohn P, Eisenberg DP, Callicott JH, Kolachana B, et al. Neanderthal-derived genetic variation is associated with functional connectivity in the brains of living humans. Brain Connect. 2021;11:38–44.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Gregory MD, Eisenberg DP, Hamborg M, Kippenhan JS, Kohn P, Kolachana B, et al. Neanderthal-derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis. Am J Med Genet B Neuropsychiatr Genet. 2021;186:329–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Trujillo CA, Rice ES, Schaefer NK, Chaim IA, Wheeler EC, Madrigal AA, et al. Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment. Science. 2021;371:eaax2573.

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Funding

MDG and KFB are supported by the NIMH Intramural Research Program (ZIAMH002652, ZIAMH002942 and ZIAMH002717).

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  1. Section on Integrative Neuroimaging, Clinical and Translational Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

    Michael D. Gregory & Karen F. Berman

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  1. Michael D. Gregory
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  2. Karen F. Berman
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MDG and KFB wrote the manuscript.

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Correspondence to Michael D. Gregory or Karen F. Berman.

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Gregory, M.D., Berman, K.F. Echoes of ancient DNA in living modern humans affect risk for neuropsychiatric disease and brain structure and function of networks subserving higher-order cognition. Neuropsychopharmacol. 48, 236–237 (2023). https://doi.org/10.1038/s41386-022-01396-0

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