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Prufer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, et al. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature. 2014;505:43–9.
Sankararaman S, Mallick S, Dannemann M, Prufer K, Kelso J, Paabo S, et al. The genomic landscape of Neanderthal ancestry in present-day humans. Nature. 2014;507:354–7.
Gregory MD, Kippenhan JS, Eisenberg DP, Kohn PD, Dickinson D, Mattay VS, et al. Neanderthal-derived genetic variation shapes modern human cranium and brain. Sci Rep. 2017;7:6308.
Gregory MD, Kippenhan JS, Kohn P, Eisenberg DP, Callicott JH, Kolachana B, et al. Neanderthal-derived genetic variation is associated with functional connectivity in the brains of living humans. Brain Connect. 2021;11:38–44.
Gregory MD, Eisenberg DP, Hamborg M, Kippenhan JS, Kohn P, Kolachana B, et al. Neanderthal-derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis. Am J Med Genet B Neuropsychiatr Genet. 2021;186:329–38.
Trujillo CA, Rice ES, Schaefer NK, Chaim IA, Wheeler EC, Madrigal AA, et al. Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment. Science. 2021;371:eaax2573.
MDG and KFB are supported by the NIMH Intramural Research Program (ZIAMH002652, ZIAMH002942 and ZIAMH002717).
The authors declare no competing interests.
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Gregory, M.D., Berman, K.F. Echoes of ancient DNA in living modern humans affect risk for neuropsychiatric disease and brain structure and function of networks subserving higher-order cognition. Neuropsychopharmacol. 48, 236–237 (2023). https://doi.org/10.1038/s41386-022-01396-0