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Single-cell transcriptional profiling in brain reward structures

Neuropsychopharmacology (2022)Cite this article

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Brain reward circuits are frequently disrupted in neuropsychiatric and substance use disorders. For example, substance use disorders are associated with prolonged molecular changes in reward-related regions including the ventral tegmental area (VTA), nucleus accumbens (NAc), prefrontal cortex, hippocampus, and amygdala. However, cellular heterogeneity has impeded progress in understanding the molecular mechanisms contributing to disease. While previous studies identified unique functions for cell types in these regions, they lacked comprehensive information on transcriptional diversity.

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Acknowledgements

The authors thank members of the Day and Martinowich labs for suggestions.

Funding

This work was supported by funding from the Lieber Institute for Brain Development as well as U01MH122849 and R01DA053581 to KM, and DP1DA039650, R01DA053743, R01MH114990, and R21DA048348 to JJD.

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Authors and Affiliations

  1. Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Jeremy J. Day

  2. Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA

    Keri Martinowich

  3. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Keri Martinowich

  4. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Keri Martinowich

  5. The Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, 21205, USA

    Keri Martinowich

Authors
  1. Jeremy J. Day
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  2. Keri Martinowich
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Contributions

JJD and KM contributed equally to the conceptualization and writing of this manuscript. Both authors approved the final version of the paper.

Corresponding authors

Correspondence to Jeremy J. Day or Keri Martinowich.

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Competing interests

KM is the Social Media Editor for Neuropsychopharmacology.

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Day, J.J., Martinowich, K. Single-cell transcriptional profiling in brain reward structures. Neuropsychopharmacol. (2022). https://doi.org/10.1038/s41386-022-01394-2

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  • DOI: https://doi.org/10.1038/s41386-022-01394-2

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